Fig. 6

Two interaction networks found in the liver of riboflavin-deficient and riboflavin-rescued embryos at e15. The top panel (a) depicts a direct gene interaction network involved in “Gene Expression” and “Protein Synthesis”. This gene network illustrates direct interactions of the apoptosis regulator BCL2 with numerous enzymes and transporters. The bottom panel (b) shows the glucocorticoid receptor (GCR) [or NR3C1] and several direct target genes; two of which (MED30 and COQ8A) interact with subunits of mitochondrial cytochrome c oxidase (COX) and NADH:ubiquinone oxidoreductase (NDUF). This network was annotated by IPA as related to “Developmental Disorder” and “Metabolic Disease”