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Table 2 Biological pathways enriched at CNVRs in the great tit genome

From: CNVs are associated with genomic architecture in a songbird

ID

Description

Number of proteins

Ajusted p-value

Protein ratio

hsa05412

Arrhythmogenic right ventricular cardiomyopathy (ARVC)

59

5.15 × 10−6

0.728

hsa04020

Calcium signaling pathway

126

1.16 × 10−4

0.583

hsa04360

Axon guidance

127

3.99 × 10−4

0.57

hsa04724

Glutamatergic synapse

78

8.2 × 10−4

0.609

hsa04514

Cell adhesion molecules (CAMs)

75

8.2 × 10−4

0.638

hsa04925

Aldosterone synthesis and secretion

60

8.2 × 10−4

0.61

hsa04713

Circadian entrainment

67

3.1 × 10−3

0.604

hsa00220

Arginine biosynthesis

19

3.15 × 10−3

0.826

hsa04970

Salivary secretion

48

1.34 × 10−2

0.615

hsa04022

cGMP-PKG signaling pathway

105

1.73 × 10−2

0.591

hsa05410

Hypertrophic cardiomyopathy (HCM)

55

1.73 × 10−2

0.536

hsa04740

Olfactory transduction

29

1.73 × 10−2

0.674

hsa05010

Alzheimer’s disease

78

3.84 × 10−2

0.545

hsa04750

Inflammatory mediator regulation of TRP channels

60

4.92 × 10−2

0.561

hsa05414

Dilated cardiomyopathy

57

4.92 × 10−2

0.564

  1. ID = pathway identification code; Description = pathway name; Number of proteins = number of protein names with genes overlapping CNVRs; Adjusted p-value = enrichment FDR corrected p-value; Protein ratio = ratio between protein names with genes in CNVRs and all protein names assigned to a specific pathway