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Table 2 Regulated canonical pathways in kidney

From: Lowered dietary phosphorus affects intestinal and renal gene expression to maintain mineral homeostasis with immunomodulatory implications in weaned piglets

Canonical pathway Regulation p-value Involved Genes
Role of NFAT in Regulation of the Immune Response L > M 1.08E-05 AKT3 (+ 1.49); CALM3 (− 1.25); CD3D (+ 1.59); CD3E (+ 1.52); FCGR3B (+ 1.64); GNAS (+ 1.33); GNG2 (+ 1.43); LCP2 (+ 1.69); NFATC2 (+ 1.51); PLCB3 (− 1.42); PLCB4 (+ 1.67)
CCR5 Signaling in Macrophages L<>M 2.33E-05 CALM3 (− 1.25); CCR5 (+ 1.76); CD3D(+ 1.59); CD3E (+ 1.52); GNAS (+ 1.33); GNG2 (+ 1.43); PRKCB (+ 1.55)
PI3K Signaling in B Lymphocytes L > M 3.17E-05 AKT3 (+ 1.49); CALM3 (− 1.25); CAMK2G (− 1.40); NFATC2 (+ 1.51); PLCB3 (− 1.42); PLCB4 (+ 1.67); PRKCB (+ 1.55); PTPRC (+ 1.86); VAV2 (− 1.37)
Phospholipase C Signaling L > M 4.59E-05 CALM3 (− 1.25); CD3D (+ 1.59); CD3E (+ 1.52); GNAS (+ 1.33); GNG2 (+ 1.43); LCP2 (+ 1.69); NFATC2 (+ 1.51); PLA2G6 (− 1.39); PLCB3 (− 1.42); PLCB4 (+ 1.67); PRKCB (+ 1.55); RHOJ (+ 1.56)
Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis L > M 4.46E-04 ADAMTS5 (+ 1.64); AKT3 (+ 1.49); CALM3 (− 1.25); CTSK (+ 1.54); FZD7 (+ 1.56); GSN (+ 1.64); IGF1 (+ 1.82); IL33 (+ 1.83); NFATC2 (+ 1.51); SPP1 (+ 2.36)
Calcium Signaling L < M 7.26E-04 ACTC1 (− 3.24); CALM3 (− 1.25); CAMK2G (− 1.40); GRIA3 (− 1.38); LETM1 (− 1.21); NFATC2 (+ 1.51); SLC8A1 (− 1.90)
LXR/RXR Activation L<>H 3.10E-03 ARG2 (− 1.48); SERPINF2 (− 3.08); TF (− 2.56)
RhoGDI Signaling L<>H 8.12E-03 ACTC1 (− 2.88); CDH2 (− 2.72); ESR1 (1.87)
  1. # - L < M = z-score ≤ − 2; L > M = z-score ≥ 2; L<>M and L<>H = no activity pattern available. P-values were calculated using Fisher’s exact test. Fold changes in parentheses indicate positive (L > M or L > H) or negative (L < M or L < H) transcript abundance