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Table 4 Statistically significant GSEA summary results in muscle of males and females (FDR < 0.05)

From: Gene co-expression networks in liver and muscle transcriptome reveal sex-specific gene expression in lambs fed with a mix of essential oils

  KEGG pathway Size ES NES FDR
Males Proteasome 34 −0.47 −3.14 0.000
Ecm Receptor Interaction 58 −0.35 −3.11 0.000
Complement and Coagulation Cascades 30 −0.41 −2.72 0.001
Spliceosome 95 −0.21 −2.32 0.012
Ribosome 36 −0.32 −2.31 0.009
Pyrimidine Metabolism 62 −0.24 −2.20 0.016
Antigen Processing and Presentation 32 −0.32 −2.15 0.020
Ppar Signaling Pathway 44 −0.26 −2.06 0.031
Rna Degradation 48 −0.25 −2.03 0.034
Peroxisome 60 −0.21 −1.96 0.046
Hematopoietic Cell Lineage 40 −0.27 −1.96 0.043
Ubiquitin Mediated Proteolysis 102 0.21 2.46 0.012
Basal Cell Carcinoma 29 0.37 2.39 0.012
Notch Signaling Pathway 37 0.33 2.33 0.015
Mapk Signaling Pathway 177 0.15 2.31 0.013
Wnt Signaling Pathway 96 0.19 2.18 0.025
Females Peroxisome 60 −0.30 −2.77 0.000
Fatty Acid Metabolism 28 −0.41 −2.62 0.001
Spliceosome 95 −0.23 −2.61 0.002
Butanoate Metabolism 20 −0.47 −2.53 0.002
Proteasome 34 −0.36 −2.52 0.002
Pyrimidine Metabolism 62 −0.24 −2.23 0.011
Ribosome 36 −0.29 −2.09 0.025
Propanoate Metabolism 23 −0.36 −2.00 0.038
Valine Leucine and Isoleucine Degradation 35 −0.28 −1.96 0.043
Nucleotide Excision Repair 37 −0.27 −1.93 0.045
Lysine Degradation 33 −0.28 −1.93 0.042
Tryptophan Metabolism 21 −0.34 −1.91 0.043
Ecm Receptor Interaction 58 0.45 4.03 0.000
Complement and Coagulation Cascades 30 0.56 3.67 0.000
Focal Adhesion 159 0.20 2.89 0.000
Hematopoietic Cell Lineage 40 0.37 2.77 0.000
Regulation Of Actin Cytoskeleton 148 0.19 2.71 0.000
Lysosome 93 0.23 2.64 0.000
Pathogenic Escherichia Coli Infection 35 0.34 2.44 0.003
Cell Adhesion Molecules Cams 57 0.26 2.31 0.006
Endocytosis 128 0.17 2.30 0.006
Sphingolipid Metabolism 23 0.38 2.21 0.011
Cytokine Cytokine Receptor Interaction 88 0.20 2.16 0.015
Pentose Phosphate Pathway 19 0.40 2.04 0.030
Leukocyte Transendothelial Migration 74 0.19 1.93 0.051
Glycolysis Gluconeogenesis 32 0.28 1.93 0.048
  1. Size = Number of genes; ES Enrichment score. ES represents the overepresentation degree of top and bottom genes included in ranked list based on log2FoldChange of DE genes included; NES Normalized enrichment score