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Table 3 Results of mediation analysis

From: Impact on birth weight of maternal smoking throughout pregnancy mediated by DNA methylation

Name ACMEa PACME ADEb PADE Totalc Ptotal Pmeth(nik)d Pnik(meth)e Pnikf
cg04865726 - 19.1 0.363 - 189 0.031 - 208 0.014 0.367 0.033 0.023
cg09662411 4.6 0.864 - 213 0.016 - 208 0.016 0.860 0.019 0.023
cg06338710 - 5.6 0.797 - 203 0.027 - 208 0.017 0.802 0.023 0.023
cg18146737 - 30.6 0.252 - 177 0.048 - 208 0.016 0.241 0.049 0.023
cg12876356 - 36.4 0.154 - 172 0.057 - 208 0.014 0.165 0.055 0.023
cg18316974 - 31.4 0.248 - 176 0.053 - 207 0.017 0.248 0.049 0.023
cg09935388 - 46.0 0.149 - 160 0.078 - 206 0.018 0.148 0.077 0.023
cg14179389 - 53.8 0.061 - 154 0.085 - 208 0.015 0.065 0.087 0.023
cg11641006 13.6 0.559 - 221 0.014 - 207 0.017 0.565 0.013 0.023
cg23067299 23.8 0.254 - 232 0.008 - 209 0.012 0.246 0.009 0.023
cg23916896 8.4 0.663 - 217 0.010 - 209 0.012 0.661 0.014 0.023
cg11902777 4.0 0.856 - 211 0.015 - 207 0.013 0.848 0.017 0.023
cg05575921 - 38.0 0.400 - 171 0.077 - 209 0.015 0.386 0.080 0.023
cg21161138 - 2.0 0.928 - 206 0.019 - 208 0.015 0.927 0.021 0.023
cg25325512 - 56.3 0.005 - 152 0.082 - 209 0.017 0.005 0.081 0.023
cg23594693 - 6.2 0.767 - 200 0.023 - 207 0.017 0.763 0.023 0.023
cg02227813 - 22.9 0.275 - 186 0.035 - 209 0.015 0.276 0.036 0.023
cg07249149 - 19.7 0.323 - 189 0.030 - 209 0.014 0.332 0.032 0.023
cg19089201 - 15.7 0.495 - 191 0.031 - 207 0.016 0.500 0.031 0.023
cg22132788 - 5.7 0.766 - 202 0.023 - 208 0.015 0.772 0.022 0.023
cg04180046 - 14.0 0.606 - 193 0.031 - 207 0.017 0.604 0.031 0.023
cg12803068 6.3 0.785 - 214 0.014 - 208 0.015 0.774 0.016 0.023
cg25949550 75.7 0.008 - 283 0.002 - 208 0.017 0.009 0.002 0.023
cg15578140 - 14.7 0.530 - 194 0.029 - 209 0.012 0.523 0.031 0.023
cg11813497 18.5 0.353 - 227 0.009 - 208 0.016 0.366 0.010 0.023
cg26033520 29.7 0.123 - 239 0.008 - 210 0.015 0.121 0.007 0.023
cg08699196 - 39.6 0.045 - 169 0.051 - 208 0.013 0.043 0.055 0.023
cg05549655 1.1 0.956 - 209 0.017 - 208 0.016 0.967 0.019 0.023
cg13859324 - 18.4 0.401 - 190 0.029 - 209 0.012 0.401 0.033 0.023
cg11043990 - 28.7 0.173 - 177 0.042 - 206 0.017 0.169 0.042 0.023
  1. aAverage causal mediation effect in g
  2. bAverage direct effect in g
  3. cTotal effect of smoking on birth weight (ACME+ADE)
  4. dAssociation between birth weight and methylation after adjustment for smoking and covariates
  5. eAssociation between birth weight and sustained maternal smoking after adjustment for methylation and covariates
  6. fAssociation between maternal smoking and birth weight after adjustment for covariates, irrespective of methylation levels