Fig. 5

miRNA-Gene-Network for the respiratory transition in Chinese giant salamander. The miRNA-Gene-Network was built using gene expression data and predicted interactions in the TargetScan miRNA database. The squares represent miRNAs and the circles represent their target genes, where red indicates up-regulation, and blue - down-regulation, purple – no significant regulation. Group1 is skin5 m and Group2 is gill5m, Group3 is lungs5 m and Group4 is lungs20m. There are four pairwise group comparisons (skin5 m vs gill5m, gill5 m vs lungs5m, gill5 m vs lungs20m and lungs5 m vs lungs20m) for differential miRNA expression regulation pattern analysis. So different proportions of different colors in squares and cycles correspond to the differential expression levels among the four groups (pairwise comparisons); for example, if half of the square is filled with red, it means that this miRNA was up-regulated in two of the four groups