| aSpecies | bDNA amount (μg) | Reads | Genome Coverage (CpG) | cInfluencing factor | Resolution | Bioinformatics requirement | Cost |
---|---|---|---|---|---|---|---|---|
Array-based methodsd | ||||||||
 MeDIP-chip | limited | 5 | – | depends on array | A, B, C, D | ~ 150 bp | ++ | ++ |
 MBD-chip | limited | 5 | – | depends on array | A, B, C, D | ~ 150 bp | ++ | ++ |
 Infinium | limited | 0.5–1 | – | 485 K | C, E, G | Single base | + | + |
NGS-based methodse | ||||||||
 MeDIP-seq | any | 0.3–5 | 50 M | ~ 23 M | A, B, D | ~  150 bp | +++ | ++ |
 MBD-seq | any | 1–3 | 30 M | ~ 23 M | A, B, D | ~  150 bp | +++ | ++ |
 RRBS | any | 0.01–2 | 10 M | ~ 2 M | E, F, G | Single base | +++ | ++ |
 MC-seq | limited | 1–3 | 50 M | 3.7 M | E, G | Single base | +++ | ++ |
 WGBS | any | 1–5 | > 500 M | > 28 M | E, G | Single base | +++++ | +++++ |