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Table 12 List of 38 human genes with a high number of human-unique motifs found in proximal and distal promoters

From: Motifome comparison between modern human, Neanderthal and Denisovan

Gene symbol

GeneCard Annotation

ANKRD11

Ankyrin Repeat Domain 11

ANO9

Anoctamin 9

C1orf170

PPARGC1 And ESRR Induced Regulator, Muscle 1

CKB

Creatine Kinase B

CUX1

Cut Like Homeobox 1

DVL1

Dishevelled Segment Polarity Protein 1

EEF1D

Eukaryotic Translation Elongation Factor 1 Delta

FGFRL1

Fibroblast Growth Factor Receptor Like 1

GNAQ

G Protein Subunit Alpha Q

IGF1R

Insulin Like Growth Factor 1 Receptor

IGF2

Insulin Like Growth Factor 2

ING2

Inhibitor Of Growth Family Member 2

KIF1A

Kinesin Family Member 1A

KLF16

Kruppel Like Factor 16

LIMD2

LIM Domain Containing 2

MTA1

Metastasis Associated 1

NOC2L

NOC2 Like Nucleolar Associated Transcriptional Repressor

NSD1

Nuclear Receptor Binding SET Domain Protein 1

POLE

DNA Polymerase Epsilon, Catalytic Subunit

PQLC1

PQ Loop Repeat Containing 1

PWWP2B

PWWP Domain Containing 2B

RAC3

Rac Family Small GTPase 3

RASA3

RAS P21 Protein Activator 3

RFNG

RFNG O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase

RUNX1

Runt Related Transcription Factor 1

SAMD11

Sterile Alpha Motif Domain Containing 11

SAMD4A

Sterile Alpha Motif Domain Containing 4A

SDC1

Syndecan 1

SEMA4C

Semaphorin 4C

SKI

SKI Proto-Oncogene

SLC19A1

Solute Carrier Family 19 Member 1

SLC2A4RG

SLC2A4 Regulator

SPHK1

Sphingosine Kinase 1

STK11

Serine/Threonine Kinase 11

SUV420H1

Lysine Methyltransferase 5B

TRIM8

Tripartite Motif Containing 8

TSEN54

TRNA Splicing Endonuclease Subunit 54

UBTF

Upstream Binding Transcription Factor, RNA Polymerase I

  1. Statistically significant human-specific motif lists (lengths 6–10) were determined for core, proximal and distal promoters. These motifs were searched for in the appropriate human promoter set. The top 100 genes with the highest number of such motifs in their promoters were listed. Those 38 genes listed below belonged to at least three top 100 lists, and were found to be in common between proximal and distal promoters