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Table 13 GO terms (biological processes) found for the 59 genes with a high number of human-unique intron motifs

From: Motifome comparison between modern human, Neanderthal and Denisovan

GO term

GO term id

No. genes

FDR

System development

GO:0048731

37

1.39E-08

Multicellular organism development

GO:0007275

38

7.48E-08

Anatomical structure development

GO:0048856

39

9.04E-08

Developmental process

GO:0032502

40

1.06E-07

Multicellular organismal process

GO:0032501

43

3.78E-07

Nervous system development

GO:0007399

25

7.65E-07

Cell-cell adhesion via plasma-membrane adhesion molecules

GO:0098742

9

3.47E-05

Cell-cell adhesion

GO:0098609

11

8.49E-05

Animal organ development

GO:0048513

25

2.47E-04

Neuron differentiation

GO:0030182

14

3.44E-04

Homophilic cell adhesion via plasma membrane adhesion molecules

GO:0007156

7

5.16E-04

Biological adhesion

GO:0022610

13

9.89E-04

Cell adhesion

GO:0007155

13

1.01E-03

Cellular developmental process

GO:0048869

26

1.19E-03

Neurogenesis

GO:0022008

16

2.13E-03

Cell differentiation

GO:0030154

25

2.70E-03

Generation of neurons

GO:0048699

15

4.06E-03

Anatomical structure morphogenesis

GO:0009653

18

5.49E-03

Neuron development

GO:0048666

11

5.75E-03

Neuromuscular process

GO:0050905

5

1.04E-02

Sensory organ development

GO:0007423

9

1.10E-02

Neuromuscular process controlling balance

GO:0050885

4

1.37E-02

Vocalization behavior

GO:0071625

3

2.08E-02

Cell projection morphogenesis

GO:0048858

8

2.63E-02

Neuron projection development

GO:0031175

9

2.64E-02

Cell development

GO:0048468

14

2.70E-02

Retina layer formation

GO:0010842

3

2.73E-02

Neuron projection morphogenesis

GO:0048812

8

2.76E-02

Plasma membrane bounded cell projection morphogenesis

GO:0120039

8

2.81E-02

Axonogenesis

GO:0007409

7

3.04E-02

Cell part morphogenesis

GO:0032990

8

3.22E-02

Cell morphogenesis

GO:0000902

9

3.59E-02

Axon development

GO:0061564

7

4.66E-02

  1. Statistically significant human-specific motif lists (lengths 6–10) were determined for introns. These motifs were searched for in the human intron sequence set. The top 100 genes with the highest number of such motifs in their introns were listed. Those 59 genes were listed which belonged to at least 3 top 100 lists, and plugged into the Gene Ontology database. Below are listed 33 GO terms associated with these 59 genes