Fig. 2
From: Low incidence of SNVs and indels in trio genomes of Cas9-mediated multiplex edited sheep
Identification of de novo SNVs through WGS of three family trios that include edited sheep. (a) The predicted off-target sites by CasOT and Cas-OFFinder at each target site. (b) The distances between 100,000 randomly selected sites (upper), and de novo SNVs (below) to predicted off-target sites. The off-target sites were defined as 1 mismatch at seed region, and up to 4 mismatch at non-seed region. The least distance to predicted off-target sites was chosen. The area between two dashlines represents the 95% confidence interval