Fig. 2
From: New genomic data and analyses challenge the traditional vision of animal epithelium evolution
Comparison of the sequences of the diagnostic domains of Par6: The N-terminal Phox and Bem1 (PB1) domains required for interaction with the PB1 domain of atypical Protein Kinase C (aPKC); the semi-CRIB (Cdc42/Rac interactive binding) domain and the C-terminal Postsynaptic-density-95/Disc-large/Zona-occludens1 (PDZ) domain required for the interaction with Par3. Sequences were aligned with MAFFT v.7 and visualized with Jalview 2.9. Critical residues are labelled in red: Lysine K19 in PB1 domain is essential for the interaction with aPKC; Proline 136 (P136) in the semi-CRIB motif is necessary to bind cdc42; Methionine 235 (M235) in the PDZ domain binds the LGL protein