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Table 3 Gene sets enriched for highly impacted genes

From: A genome-wide survey of mutations in the Jurkat cell line

GO: CHROMOSOME ORGANIZATION
Overlap: 51/1009 p-value= 0.00011
Genes: APBB1, ATXN3, ATXN7, BAZ2A, BCORL1, BRD8, CDC14A, CDCA5, CDYL, CENPT, CLASP1,
CREBBP, EHMT1, GATAD2B, GTF2H3, HDAC4, KAT2A, KDM5B, KIF23, KNTC1, MLH3, MSH2,
NCAPD2, NDC80, NOC2L, PIBF1, PRIM2, PTGES3, RAD50, RBL2, RSF1, SETX, SLX4, SMARCC2,
SMC3, TCF7L2, TEP1, TET1, TEX14, TOP1MT, TP53, TTN, USP15, VPRBP, YEATS2, ZNF304, ZNF462
GO: CELL CYCLE
Overlap: 62/1316 p-value= 0.00015
Genes: ADCY3, ANAPC5, APBB1, ARHGEF2, BAX, CDC14A, CDC27, CDCA5, CDK14, CECR2,
CENPT, CEP164, CKAP2, CLASP1, DYNC1H1, DYNC1I2, FANCI, HINFP, HSP90AA1, INTS3,
IQGAP3, KIAA0430, KIAA1377, KIF23, KNTC1, KRT18, MACF1, MAP3K8, MAP9, MCM8,
MKI67, MLH3, MNS1, MSH2, NCAPD2, NDC80, NUP214, NUP98, OFD1, ORC1, PHLDA1,
PIBF1, PRIM2, PSMD3, PTEN, PYHIN1, RAD50, RBL2, RUVBL1, SMC3, SON, TCF7L2, TEX14,
THAP1, TP53, TP53BP1, TPR, TRIOBP, TSC1, TTK, TTN, ZFHX3
GO: CARBOHYDRATE DERIVATIVE BIOSYNTHETIC PROCESS
Overlap: 34/595 p-value= 0.00017
Genes: ADCY2, ADCY3, ADCY9, ALG1L2, ALG9, B3GALT1, B3GNT6, BCAN, BMPR2, C1GALT1C1,
CANT1, CHST15, CHSY1, GAL3ST4, GPC6, GUCY2C, GXYLT1, HAS3, KIAA2018, MUC16, MUC19,
MUC3A, MUC6, NDST4, OMD, PHLDA1, PIGS, PRKCSH, SLC25A13, ST3GAL3, ST3GAL5, TET1,
UGCG, UGP2
GO: NEGATIVE REGULATION OF ORGANELLE ORGANIZATION
Overlap: 25/387 p-value= 0.00020
Genes: ARHGEF2, CDC14A, CKAP2, CLASP1, DYNC1H1, KIAA1377, KIF23, LIMA1, MAP9, MSH2,
NDC80, NOC2L, OFD1, OTUB1, PIBF1, RAD50, SMC3, SPTA1, SPTAN1, TET1, TEX14, TPR, TRIOBP,
TTK, UBQLN4
GO: IMMUNE SYSTEM PROCESS
Overlap: 85/1984 p-value= 0.00023
Genes: ABCB5, ADAM17, AGBL5, AIM2, AP3B1, APOB, ARHGEF2, BAX, C1orf177, C7, CCL13,
CD14, CD177, CEACAM8, CLNK, CREBBP, CTLA4, CYFIP2, DEFB126, DHX58, DYNC1H1,
DYNC1I2, DYNC2H1, ENDOU, ENPP3, F2, FN1, HDAC4, HLA-DRB5, HNRNPK, HSH2D,
HSP90AA1, IGJ, IL10RB, IL27RA, IL2RG, ILF2, INPP5D, IPO7, ITGA6, KIF23, KIF3C, KIR2DS4,
KLC2, LILRA3, MAP3K1, MAP3K8, MSH2, NCAM1, NLRC3, NLRC5, OAS1, OTUB1, PAPD4,
PIBF1, PODXL, PRKACG, PSMD3, PTEN, RHOH, SAMHD1, SARM1, SEC31A, SECTM1, SHC1,
SLC3A2, SLFN11, SPEF2, SPTA1, STAT5B, SYK, SYNCRIP, TAB2, TAPBP, TEK, TMIGD2, TNFSF4,
TNK2, TRIL, TRIM10, TSC1, ULBP1, VPRBP, WDR7, WIPF1