Table 3 Gene sets enriched for highly impacted genes

GO: CHROMOSOME ORGANIZATION

Overlap: 51/1009 p-value= 0.00011

Genes: APBB1, ATXN3, ATXN7, BAZ2A, BCORL1, BRD8, CDC14A, CDCA5, CDYL, CENPT, CLASP1,

CREBBP, EHMT1, GATAD2B, GTF2H3, HDAC4, KAT2A, KDM5B, KIF23, KNTC1, MLH3, MSH2,

NCAPD2, NDC80, NOC2L, PIBF1, PRIM2, PTGES3, RAD50, RBL2, RSF1, SETX, SLX4, SMARCC2,

SMC3, TCF7L2, TEP1, TET1, TEX14, TOP1MT, TP53, TTN, USP15, VPRBP, YEATS2, ZNF304, ZNF462

GO: CELL CYCLE

Overlap: 62/1316 p-value= 0.00015

Genes: ADCY3, ANAPC5, APBB1, ARHGEF2, BAX, CDC14A, CDC27, CDCA5, CDK14, CECR2,

CENPT, CEP164, CKAP2, CLASP1, DYNC1H1, DYNC1I2, FANCI, HINFP, HSP90AA1, INTS3,

IQGAP3, KIAA0430, KIAA1377, KIF23, KNTC1, KRT18, MACF1, MAP3K8, MAP9, MCM8,

MKI67, MLH3, MNS1, MSH2, NCAPD2, NDC80, NUP214, NUP98, OFD1, ORC1, PHLDA1,

PIBF1, PRIM2, PSMD3, PTEN, PYHIN1, RAD50, RBL2, RUVBL1, SMC3, SON, TCF7L2, TEX14,

THAP1, TP53, TP53BP1, TPR, TRIOBP, TSC1, TTK, TTN, ZFHX3

GO: CARBOHYDRATE DERIVATIVE BIOSYNTHETIC PROCESS

Overlap: 34/595 p-value= 0.00017

Genes: ADCY2, ADCY3, ADCY9, ALG1L2, ALG9, B3GALT1, B3GNT6, BCAN, BMPR2, C1GALT1C1,

CANT1, CHST15, CHSY1, GAL3ST4, GPC6, GUCY2C, GXYLT1, HAS3, KIAA2018, MUC16, MUC19,

MUC3A, MUC6, NDST4, OMD, PHLDA1, PIGS, PRKCSH, SLC25A13, ST3GAL3, ST3GAL5, TET1,

UGCG, UGP2

GO: NEGATIVE REGULATION OF ORGANELLE ORGANIZATION

Overlap: 25/387 p-value= 0.00020

Genes: ARHGEF2, CDC14A, CKAP2, CLASP1, DYNC1H1, KIAA1377, KIF23, LIMA1, MAP9, MSH2,

NDC80, NOC2L, OFD1, OTUB1, PIBF1, RAD50, SMC3, SPTA1, SPTAN1, TET1, TEX14, TPR, TRIOBP,

TTK, UBQLN4

GO: IMMUNE SYSTEM PROCESS

Overlap: 85/1984 p-value= 0.00023

Genes: ABCB5, ADAM17, AGBL5, AIM2, AP3B1, APOB, ARHGEF2, BAX, C1orf177, C7, CCL13,

CD14, CD177, CEACAM8, CLNK, CREBBP, CTLA4, CYFIP2, DEFB126, DHX58, DYNC1H1,

DYNC1I2, DYNC2H1, ENDOU, ENPP3, F2, FN1, HDAC4, HLA-DRB5, HNRNPK, HSH2D,

HSP90AA1, IGJ, IL10RB, IL27RA, IL2RG, ILF2, INPP5D, IPO7, ITGA6, KIF23, KIF3C, KIR2DS4,

KLC2, LILRA3, MAP3K1, MAP3K8, MSH2, NCAM1, NLRC3, NLRC5, OAS1, OTUB1, PAPD4,

PIBF1, PODXL, PRKACG, PSMD3, PTEN, RHOH, SAMHD1, SARM1, SEC31A, SECTM1, SHC1,

SLC3A2, SLFN11, SPEF2, SPTA1, STAT5B, SYK, SYNCRIP, TAB2, TAPBP, TEK, TMIGD2, TNFSF4,

TNK2, TRIL, TRIM10, TSC1, ULBP1, VPRBP, WDR7, WIPF1