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Table 2 A catalogue of downregulated proteins identified using iTRAQ labeling method An. culicifacies in species B

From: Proteome-wide analysis of Anopheles culicifacies mosquito midgut: new insights into the mechanism of refractoriness

S.no UniProt no. Protein ∑ coverage Peptides M.wt (kDa) Function Ratio
1. B0WZ30 Histone H2B (similar to Culex quinquefasciatus) 32 5 13.8 DNA binding 0.61
2. Q1HQX3 AAEL012326-PA (similar to Aedes aegypti) 31 6 16.8 calcium ion binding 0.62
3. F5HME4 AGAP001799-PB (similar to Anopheles gambiae) 24 8 32.4 Unknown 0.61
4. Q7PJV2 AGAP010147-PA (similar to Anopheles gambiae) 23 56 224.2 ATP binding, motor activity 0.60
5. B0X773 Histone H2A (similar to Culex quinquefasciatus) 20 4 13.3 DNA binding 0.43
6. Q5TMR7 AGAP011939-PA (similar to Anopheles gambiae) 20 7 35.9 catalytic activity 0.43
7. Q1HRH7 Catalase (Fragment) (similar to Aedes aegypti) 20 8 48.5 catalytic activity 0.39
8. Q380N3 AGAP001797-PA (similar to Anopheles gambiae) 17 17 84.3 Unknown 0.44
9. Q7Q3D8 AGAP007827-PA (similar to Anopheles gambiae) 15 10 46.6 phosphopyruvate hydratase activity 0.068
10. Q7QA89 AGAP004366-PA (similar to Anopheles gambiae) 11 8 63.5 oxidoreductase activity 0.60
11. Q7Q5J5 AGAP006398-PA (similar to Anopheles gambiae) 10.34 3 31.2 unknown function 0.56
12. F5HKV6 Fructose-bisphosphate aldolase (similar to Anopheles gambiae) 9.64 4 39.2 aldolase activity 0.66
13. Q7QDY3 AGAP010479-PA (similar to Anopheles gambiae) 7.86 4 45.0 unknown 0.62
14. Q7PQK5 AGAP004192-PA (similar to Anopheles gambiae) 7.13 6 72.7 Protein folding 0.62
15. Q7Q609 AGAP006099-PA (similar to Anopheles gambiae) 6.61 4 45.1 metal ion binding, catalytic activity 0.45
16. Q7QHE7 AGAP011158-PA (Fragment) (similar to Anopheles gambiae) 6.15 3 51.5 pyridoxal phosphate binding 0.64
17. Q7Q5T1 AGAP006225-PA (similar to Anopheles gambiae) 5.14 8 138.7 oxidoreductase activity 0.53
18. T1DPT6 Malic enzyme (Fragment) (similar to Anopheles aquasalis) 4.43 3 79.2 metal ion binding 0.45
19. F5HLD4 AGAP003656-PB (similar to Anopheles gambiae) 4.12 18 450.9 protein binding, Immunoglobulin-like domains 0.65
20. A0A084VWP1 AGAP001797-PE-like protein (similar to Anopheles sinensis) 17 6 41.657 tropomyosin 0.48
21. T1DN92 Putative voltage-dependent anion-selective channel (similar to An. aquasalis) 8 2 38.131 voltage-gated anion channel activity 0.57
22. Q17GL0 AAEL002978-PA (similar to Aedes aegypti) 10 5 65.476 aminopeptidase activity 0.5
23. A0A023EEY5 Putative cytochrome c (similar to Aedes albopictus) 21 2 16.3 electron carrier activity 0.62
24. B0WKF4 Pyrroline-5-carboxylate dehydrogenase (similar to Culex quinquefasciatus) 10 6 77.7 oxidoreductase activity 0.56
25. A0A023EGV4 Putative calmodulin (similar to Aedes albopictus) 25 5 19.538 calcium ion binding 0.27
26. A0A084VKA2 Calreticulin (similar to Anopheles sinensis) 7 4 59.369 calcium ion binding 0.5
27. Q7Q343 AGAP011476-PA (similar to Anopheles gambiae) 7 5 105.89 amidase activity 0.45
28. A0A084WD61 AGAP007990-PA-like protein (similar to Anopheles sinensis) 4 3 655.68 glucuronosyl transferase activity 0.53
29. A0A023EJ61 Putative 2-cys thioredoxin peroxidase (similar to Aedes albopictus) 9 2 267.66 peroxidase activity 0.33
30. Q7QGY7 AGAP010957-PA, partial (similar to Anopheles gambiae) 24 5 199.5 calcium ion binding 0.27
31. B0WED4 Deoxyuridine 5′-triphosphate nucleotidohydrolase(similar to Culex quinquefasciatus) 21 3 15.9 Diphosphatase activity 0.543
32. Q7QFS4 AGAP003869-PA (similar to Anopheles gambiae) 11.29 6 54 Aminopeptidase activity 0.646
33. Q7Q3R0 AGAP007990-PA (similar to Anopheles gambiae) 10.22 6 61.4 transferase activity 0.380
34. Q7QEF5 AGAP000679-PA (similar to Anopheles gambiae) 9 4 46.4 Aminoacylase activity 0.585
35. A0NFA5 AGAP007790-PA (similar to Anopheles gambiae) 7.32 4 35.5 Ion transport 0.291
36. A0NDL8 AGAP003713-PA (similar to Anopheles gambiae) 6.84 1 12.8 Unknown 0.316
37. Q16V79 AAEL009658-PB (similar to Aedes aegypti) 6.84 4 66.9 Alpha trehalase activity/ catalytic activity 0.606
38. B0W447 Carbonic anhydrase (similar to Culex quinquefasciatus) 5.76 2 31.5 carbonate dehydratase activity 0.450
39. Q7QF10 AGAP000249-PA (similar to Anopheles gambiae) 4.30 4 69.7 mannosyl-glycoprotein endo-beta-N-acetyl glucosaminidase activity 0.520
40. Q7PV84 AGAP012302-PA (similar to Anopheles gambiae) 3.66 2 71.1 sulfate transmembrane transporter activity 0.405
41. Q7QAH7 AGAP003695-PA (similar to Anopheles gambiae) 3.48 5 105.5 metallopeptidase activity 0.577