Table 2 Results of the gene enrichment analysis
From: Additional oxidative stress reroutes the global response of Aspergillus fumigatus to iron depletion
Comparison | Up- | Down- | Significant enriched FunCat termsa | |
|---|---|---|---|---|
regulated genes | for up regulated genes | for down regulated genes | ||
-Fe/-H2O2 vs. +Fe/-H2O2 | 1107 | 1383 | secondary metabolism, drug/toxin transport, homeostasis of metal ions, siderophore-iron transport, degradation of aspartate | translation, Fe/S binding, ribosome biogenesis, secondary metabolism, aerobic respiration, detoxification involving cytochrome P450, heme binding, TCA pathway, metabolism of melanins, catalase reaction |
+Fe/+H2O2 vs. +Fe/-H2O2 | 347 | 339 | secondary metabolism | secondary metabolism, siderophore-iron transport, extracellular polysaccharide degradation, homeostasis of metal ions |
-Fe/+H2O2 vs. -Fe/-H2O2 | 2125 | 2028 | proteasomal degradation, heat shock response, vacuolar/lysosomal transport, oxidative stress response, DNA repair | ribosome biogenesis, translation, allantoin and allantoate transport, secondary metabolism, vitamin/cofactor transport, fatty acid metabolism, virulence and disease factors, degradation of glutamine |
-Fe/+H2O2 vs. +Fe/-H2O2 | 2420 | 2344 | vacuolar/lysosomal transport, heat shock response, proteasomal degradation, transcription initiation, vacuole or lysosome, DNA repair | ribosome biogenesis, translation, Fe/S binding, TCA pathway, secondary metabolism, aerobic respiration, detoxification involving cytochrome P450, allantoin and allantoate transport, disease-virulence-defense, heme binding |