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Table 4 Regulation of selected secondary metabolism biosynthetic gene clusters

From: Additional oxidative stress reroutes the global response of Aspergillus fumigatus to iron depletion

Cluster Cluster sizea Related genes (up-regulated/down-regulated)
-Fe/-H2O2 vs. +Fe/-H2O2 +Fe/+H2O2 vs. +Fe/-H2O2 -Fe/+H2O2 vs. -Fe/-H2O2 -Fe/+H2O2 vs. +Fe/-H2O2
DHN-melanin cluster 10 1/8b 1/0 3/0 2/7b
Endocrocin cluster 9 2/4b 5b/1 1/4 1/5b
Fumagillin cluster 15 8b/0 11b/0 0/15b 1/2
Fumigaclavine C (fga) cluster 11 0/5b 4b/0 0/1 0/6b
Fumipyrrole cluster 7 0/7b 0/0 2/1 1/7b
Fumiquinazoline cluster 5 0/5b 1/0 1/0 0/4b
Fumitremorgin B (ftm) cluster 9 0/4b 0/0 0/7b 0/8b
Siderophore cluster 18 10b/5 0/10b 9b/3 11b/3
Gliotoxin (gli) cluster 12 0/12b 2/0 4/1 0/12b
Hexadehydro-astechrome cluster 8 7b/0 5b/0 1/4 3/0
Pseurotin A cluster 4 3b/0 4b/0 0/4b 0/1
Afu1g01010 cluster 4 2/0 1/0 0/4b 0/1
Afu3g01410 cluster 9 2/0 2b/0 3/4 2/3
Afu3g02570 and Afu3g02530 clusters 15 4/3 0/2 7b/0 6/2
Afu3g02670 cluster 7 3b/0 0/1 1/2 3/0
Afu3g13730 cluster 9 0/5b 0/4b 0/1 0/5b
Afu5g10120 cluster 10 3/0 1/0 2/0 6b/0
Afu6g13930 cluster 9 0/9b 0/2b 1/5b 0/9b
Afu7g00170 cluster 7 1/1 4b/0 1/0 1/0
No PKS or NRPS backbone 6 cluster 13 1/5b 0/2 3/1 3/5
Number of up-regulated clusters   5 7 2 2
Number of down-regulated clusters   10 3 5 9
  1. aNumber of genes belonging to the cluster. The full data sets are available in Additional file 4
  2. bSignificantly enriched gene group according to the Fisher’s exact test (p < 0.05)