Table 4 Regulation of selected secondary metabolism biosynthetic gene clusters
From: Additional oxidative stress reroutes the global response of Aspergillus fumigatus to iron depletion
Cluster | Cluster sizea | Related genes (up-regulated/down-regulated) | |||
|---|---|---|---|---|---|
-Fe/-H2O2 vs. +Fe/-H2O2 | +Fe/+H2O2 vs. +Fe/-H2O2 | -Fe/+H2O2 vs. -Fe/-H2O2 | -Fe/+H2O2 vs. +Fe/-H2O2 | ||
DHN-melanin cluster | 10 | 1/8b | 1/0 | 3/0 | 2/7b |
Endocrocin cluster | 9 | 2/4b | 5b/1 | 1/4 | 1/5b |
Fumagillin cluster | 15 | 8b/0 | 11b/0 | 0/15b | 1/2 |
Fumigaclavine C (fga) cluster | 11 | 0/5b | 4b/0 | 0/1 | 0/6b |
Fumipyrrole cluster | 7 | 0/7b | 0/0 | 2/1 | 1/7b |
Fumiquinazoline cluster | 5 | 0/5b | 1/0 | 1/0 | 0/4b |
Fumitremorgin B (ftm) cluster | 9 | 0/4b | 0/0 | 0/7b | 0/8b |
Siderophore cluster | 18 | 10b/5 | 0/10b | 9b/3 | 11b/3 |
Gliotoxin (gli) cluster | 12 | 0/12b | 2/0 | 4/1 | 0/12b |
Hexadehydro-astechrome cluster | 8 | 7b/0 | 5b/0 | 1/4 | 3/0 |
Pseurotin A cluster | 4 | 3b/0 | 4b/0 | 0/4b | 0/1 |
Afu1g01010 cluster | 4 | 2/0 | 1/0 | 0/4b | 0/1 |
Afu3g01410 cluster | 9 | 2/0 | 2b/0 | 3/4 | 2/3 |
Afu3g02570 and Afu3g02530 clusters | 15 | 4/3 | 0/2 | 7b/0 | 6/2 |
Afu3g02670 cluster | 7 | 3b/0 | 0/1 | 1/2 | 3/0 |
Afu3g13730 cluster | 9 | 0/5b | 0/4b | 0/1 | 0/5b |
Afu5g10120 cluster | 10 | 3/0 | 1/0 | 2/0 | 6b/0 |
Afu6g13930 cluster | 9 | 0/9b | 0/2b | 1/5b | 0/9b |
Afu7g00170 cluster | 7 | 1/1 | 4b/0 | 1/0 | 1/0 |
No PKS or NRPS backbone 6 cluster | 13 | 1/5b | 0/2 | 3/1 | 3/5 |
Number of up-regulated clusters | Â | 5 | 7 | 2 | 2 |
Number of down-regulated clusters | Â | 10 | 3 | 5 | 9 |