Fig. 5

Waveband specific differential transcriptional regulation of the epidermal growth factor (EGF) pathway. The EGF pathway is suppressed when fish are exposed to 4100 K FL or 520–530 nm waveband light (top and bottom). In these two cases, the transmembrane EGF receptor is down-modulated as are many downstream gene targets of the pathway. However, when the fish are exposed to 450–500 nm waveband light (center) EGF transcription is up-modulated. The EGFR is present and predicted to be ligand bound leading to up-regulated transcription of most downstream targets. Each molecule differentially up modulated is represented in red and down represented in green. Downstream effects are predicted to be activated (orange) or suppressed (blue) based on IPA z-score. Complexes consist of multiple genes represented by a single symbol in the figure (4100 K: PI3K-TLR9, PIK3R6, ATM; SOS-SOS1, SOS2; ITPR-ITPR2; CK2-CSNK2A, CSNK2B. 450–500 nm: SOS-SOS2; ITPR-ITPR2, ITPR3; PI3K-TLR9, IRS1, FGFR1, FGFR2, IRS2, PIK3R3; AKT-AKT1, AKT3. 520–530 nm: ITPR-ITPR3, PI3K-ATM, FGFR1, FGFR2, IRS1, PIK3R2; PKCα: PRKCA)