Table 9 Ingenuity Pathway Analysis: main pathways impacted by hydrolysate-supplemented diets
TH diet versus FM5 diet | SH diet versus FM5 diet | MH diet versus FM5 diet |
|---|---|---|
Top Canonical Pathways (Name/p-value/Overlap) | Top Canonical Pathways (Name/p-value/Overlap) | Top Canonical Pathways (Name/p-value/Overlap) |
Glycolysis I/1.23E-03/8% | Role of Lipids/Lipid Rafts in the Pathogenesis of Influenza/9.11E-04/9.1% | Superpathway of Cholesterol Biosynthesis/2.13E-17/42.9% |
Gluconeogenesis I/1.23E-03/8% | Glutamine Biosynthesis I/2.04E-03/100% | Cholesterol Biosynthesis I/6.27E-16/69.2% |
Glutamine Biosynthesis I/2.08E-03/100% | Xanthine and Xanthosine Salvage/2.04E-03/100% | Cholesterol Biosynthesis II (via 24.25-dihydrolanosterol) / 6.27E-16/69.2% |
FXR/RXR Activation/2.30E-03/2.4% | Type II Diabetes Mellitus Signalling/2.20E-03/2.4% | Cholesterol Biosynthesis III (via Desmosterol)/6.27E-/ 69.2% |
IL-17A Signalling in Fibroblasts/2.41E-03/5.7% | IL-17A Signalling in Fibroblasts/2.31E-03/5.7% | Zymosterol Biosynthesis/1.48E-07/66.7% |
Molecular and Cellular Functions (Name/p-value/#Molecules) | Molecular and Cellular Functions (Name/p-value/#Molecules) | Molecular and Cellular Functions (Name/p-value/#Molecules) |
Cell Morphology/2.27E-02 - 1.27E-05/9 | Cell Death and Survival/1.73E-02 - 1.81E-05/14 | Lipid Metabolism/6.58E-03 - 2.66E-14/79 |
Carbohydrate Metabolism/2.67E-02 - 6.33E-05/9 | Cell-To-Cell Signalling and Interaction/1.62E-02 - 2.68E-05/10 | Small Molecule Biochemistry/6.58E-03 - 2.66E-14/106 |
Small Molecule Biochemistry/2.75E-02 - 6.33E-05/20 | Cellular Development 1.72E-02 -/3.65E-05/15 | Vitamin and Mineral Metabolism/6.25E-03 - 1.96E-11/30 |
Amino Acid Metabolism/2.67E-02 - 2.76E-04/4 | Cellular Function and Maintenance/1.73E-02 - 3.65E-05/14 | Molecular Transport/6.25E-03 - 3.02E-10/74 |
Post-Translational Modification/1.24E-02 - 2.76E-04/2 | Cellular Growth and Proliferation/1.72E-02 - 3.65E-05/12 | Carbohydrate Metabolism/6.25E-03 - 1.60E-08/43 |