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Table 3 Rank and fold change of enrichment of significant aseQTLs and eQTLs at putative bovine CTCF binding motifs

From: Putative bovine topological association domains and CTCF binding motifs can reduce the search space for causative regulatory variants of complex traits

QTL type cell type P-value significant threshold Less stringent More stringent
rank fold change rank fold change
aseQTL white blood 10−5 <0.0001 1.54 <0.0001 4.19
10−6 <0.0001 1.55 <0.0001 4.07
10−7 <0.0001 1.55 <0.0001 4.02
10−8 <0.0001 1.56 <0.0001 3.96
milk 10−5 <0.0001 1.49 <0.0001 3.97
10−6 <0.0001 1.49 <0.0001 3.71
10−7 <0.0001 1.49 <0.0001 3.67
10−8 <0.0001 1.48 <0.0001 3.61
eQTL white blood 10−5 <0.0001 1.38 <0.0001 3.97
10−6 <0.0001 1.43 <0.0001 3.56
10−7 <0.0001 1.45 <0.0001 2.75
10−8 <0.0001 1.47 <0.0001 2.66
milk 10−5 <0.0001 1.34 <0.0001 4.48
10−6 <0.0001 1.40 <0.0001 4.75
10−7 <0.0001 1.38 <0.0001 4.05
10−8 <0.0001 1.53 0.9978 3.44
  1. The levels of enrichment of significant allele-specific expression quantitative trait loci (aseQTL) and expression quantitative trait loci (eQTL) from bovine white blood cells and milk cells at two sets of putative bovine CTCF binding motifs are presented. The significance is defined by a P-value less than 10−5, 10−6, 10−7and 10−8 in aseQTL mapping and eQTL mapping respectively. A less stringent set of putative bovine CTCF binding motifs has motif P-value no larger than 10−5. A more stringent set of putative bovine CTCF binding motifs has motif P-value no larger than 10−8 and motif score no smaller than 80