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Table 4 eGenes are often located within the same TAD as their linearly-furthermost, and most-significant, aseQTL/eQTL

From: Putative bovine topological association domains and CTCF binding motifs can reduce the search space for causative regulatory variants of complex traits

QTL type Cell type maximum number of eSNPs tested in a chromosome Sourced TAD set number of significant eGene in TAD number of furthermost and most-significant cis-QTL-eGene in the same TAD Chi-Square test
Expected observed value P-value
aseQTL white blood 1,057,269 hg18:hESC 13,302 1406.379224 6375 17,553.7238 0
hg18:IMR90 13,790 1457.973951 7273 23,192.8204 0
mm9:mESC 13,641 1442.220643 7682 26,996.4562 0
mm9:cortex 13,150 1390.308735 8670 38,116.6453 0
mm10:liver 12,013 1270.09725 5101 11,554.8757 0
canfam3:liver 13,046 1379.313137 6086 16,060.8209 0
milk 1,153,815 hg18:hESC 9553 1102.23947 3862 6909.82168 0
hg18:IMR90 10,019 1156.007249 4550 9964.63198 0
mm9:mESC 9706 1119.892839 4764 11,857.8462 0
mm9:cortex 9317 1075.009436 5608 19,114.2541 0
mm10:liver 8692 1002.895998 2931 3706.85001 0
canfam3:liver 9638 1112.046897 3863 6805.23726 0
eQTL white blood 8964 hg18:hESC 327 0.2931228 114 44,108.66 0
hg18:IMR90 340 0.304776 125 51,017.4649 0
mm9:mESC 322 0.2886408 125 53,883.3149 0
mm9:cortex 305 0.273402 123 55,090.3719 0
mm10:liver 284 0.2545776 91 32,346.6467 0
canfam3:liver 330 0.295812 119 47,633.917 0
milk 2463 hg18:hESC 343 0.0844809 24 6770.19366 0
hg18:IMR90 348 0.0857124 25 7241.9128 0
mm9:mESC 356 0.0876828 34 13,115.9732 0
mm9:cortex 323 0.0795549 36 16,218.7166 0
mm10:liver 340 0.083742 23 6271.10507 0
canfam3:liver 362 0.0891606 22 5384.49588 0
  1. The linearly-furthermost, and most-significant, aseQTL and eQTL for each eGene all have a P-value less than 10−8 in aseQTL/eQTL mapping