Fig. 1

Expression profiles of the CCHCR1-HEK293 cell lines. a Venn diagrams of differentially expressed genes (DEGs) of the CCHCR1-HEK293 cell lines; Iso1Non-risk (1 N), Iso1Risk (1R), Iso3Non-risk (3 N), and Iso3Risk (3R), when compared with vector and wild type controls (FC > 1.5 or FC < 0.75, FDR < 0.25). The most highlighted functions and pathways of the gene enrichment analysis of DEGs that were shared by the all four cell lines are shown. Up- and downregulated genes were analyzed separately (see in detail Additional file 3: Table S3). b Principal component analysis (PCA) demonstrates differences between CCHCR1-HEK293 cell lines. The two PCs depict the variation between samples. The PC2 illustrates the isoform-dependent difference, clustering isoforms 1 and 3 as separate groups. The wild type (wt) and vector (v) control samples cluster as an overlapping group between the isoform 1 and isoform 3 samples