Fig. 3

Gene expression profiles of Wnt and RIG-I-like signaling in the CCHCR1-HEK293 cell lines. Both pathways were highlighted in the CCHCR1 cell lines. Heatmaps of Wnt (a) and RIG-I-like (RLR) (b) signaling in the Iso1Non-risk (IN), Iso1Risk (1R), Iso3Non-risk (3 N), and Iso3Risk (3R) CCHCR1 cell lines, vector transfected cells (v), and wild type HEK293 (wt) demonstrated that there were differences between cell lines. Wnt signaling is mainly upregulated only in the Iso3Non-risk cells while RLR signaling shows more downregulation in Iso3Risk than in other cell lines. Color key: red represents upregulated and blue downregulated expression (row Z-score). c The expression of CXCL8 in the CCHCR1-HEK293 cell lines was validated with qPCR, and compared with the gene expression in the wild type cells. Here shown normalization with HPRT1. Error bars: standard deviation