Skip to main content
Fig. 4 | BMC Genomics

Fig. 4

From: Modifier locus mapping of a transgenic F2 mouse population identifies CCDC115 as a novel aggressive prostate cancer modifier gene in humans

Fig. 4

TCGA Cohort of candidate gene expression profiles. a. Comparison of differential expression between normal prostate (PAN) Vs adenocarcinoma tissue (PCa) for five candidate genes. b. Survival plot for cases with dysregulation of all 4 candidate genes CCDC115, DNAJC10, RNF149 and STYXL1 (red) compared to cases with normal expression (blue). c. Survival plot of cases with upregulated DNACJ10 expression (red) compared to cases with normal DNAJC10 expression levels (blue). d. Survival plot of cases with CCDC115 dysregulation (red) compared to all cases without CCDC115 differential expression (blue). e. Survival plot of those cases with dysregulated CCDC115 expression comparing loss of CCDC115 expression (blue) and upregulated CCDC115 expression (red). f. Oncoprint showing prostate tumor expression changes in individual cases for each candidate gene (red = upregulated; blue = down regulated). ***p < 0.001

Back to article page

BMC Genomics

ISSN: 1471-2164

Contact us