Table 2 Candidate genes that suppress par-4-dependent hyperplasia during the dauer stage

H26D21.1^a

hus-1

DNA damage checkpoint protein required for DNA damage-induced cell cycle arrest in C. elegans

C43E11.6

nab-1

Neurabin orthologue that regulate interactions between actin and microtubules during cell division, migration and growth cone guidance

F27C1.7^a

atp-3

Subunit of mitochondrial ATP synthase, which regulates growth rate, body size, and ageing.

C34G6.6^a

noah-1

ECM component required for molting, development, vulval development, and normal body morphology

H15N14.1

adr-1

Adenosine deaminase that acts on RNA by deaminating adenosines and generating inosines in dsRNA; protects transgenic RNA from RNAi silencing

C54G4.8^a

cyc-1

Subunit of complex III cytochrome c reductase required for normal ATP production

F26E4.9^a

cco-1

Subunit of cytochrome c oxidase-1, a component the electron transport chain in mitochondria

E03H4.8^a

Uncharacterized

H28O16.1^a

Uncharacterized

M01D7.1^a

Uncharacterized

ZK1151.1

vab-10

A spectraplakin, component of the hemidesmosome in C. elegans; required for transducing mechanical signals from muscle cells to epidermis, and DTC migration

B0414.2

rnt-1

Transcription factor required for seam cell proliferation; interacts with SMA-4 and regulates expression of CDK- inhibitor cki-1

T15H9.3^a

hlh-6

Helix loop helix transcription factor

C47D12.6^a

tars-1

Threonyl amino-acyl tRNA synthetase

ZK930.3^a

vab-23

Transcription factor involved in ventral closure, elongation

W08F4.6^a

mlt-8

Putative signalling peptide secreted from cells involved in the L2/L3 molting process

W03C9.3

rab-7

Rab-GTPase required for endosome to lysosome trafficking

F59G1.3^a

vps-35

Vacuolar protein sorting factor

R09D1.7^a

chil-20

Chitinase-like protein

C41C4.4^a

ire-1

Transmembrane serine/threonine kinase and endoribonuclease necessary for unfolded protein response (UPR)

F10B5.1^a

rpl-10

Ribosomal subunit L10

T05G5.3

cdk-1

Cyclin-dependent kinase required for cell cycle progression through the G2/M checkpoint

R01H10.1^a

div-1

DNA polymerase subunit required for normal interphase timing and asymmetric distribution of PIE-1 and P granules

K12H4.4

Uncharacterized

C04D8.1

pac-1

Rho-GAP involved in establishing radial asymmetry during C. elegans development by regulating the spatial localization of CDC-42

F43C1.2^a

mpk-1

Mitogen-activated-protein-kinase

F58A4.8

tbg-1

γ-tubulin

K08E3.6

cyk-4

Rho-GAP and member of the centralspindlin complex required for cytokinesis; also factor localized to intercellular bridge in the rachis required for gonad structural integrity

R10E11.2^a

vha-2

V-ATPase subunit involved in protein sorting and receptor mediated endocytosis

F26A1.14^a

Uncharacterized

H19M22.2^a

let-805

Myotactin; subunit of the hemidesmosome complex

F26F4.10

rars-1

Arginyl-tRNA synthetase

F02A9.6

glp-1

Notch receptor homologue and required for germline proliferation

M88.6

pan-1

Transmembrane protein required for completion of larval molts; expression enriched in the germ line

B0336.2

arf-1.2

ADP-ribosylation factor homolog, a GTPase that regulates intracellular trafficking and the actin cytoskeleton

T12A2.2^a

stt-3

Yeast oligosaccharyltransferase subunit homologue

F37C12.4

rpl-36

Large ribosomal subunit L36

F58A4.11^a

gei-13

Predicted DNA binding protein involved in body shape regulation, cuticle synthesis and locomotion

C46A5.2

del-7

Degenerin-like protein; degenerin family of proteins are sodium ion channels essential for homeostasis and involved in mechanotransduction

F56H11.1^a

fbl-1

Fibulin, a component of the extracellular matrix required for DTC migration initiation

F56H9.5^a

lin-25

Subunit of the Mediator complex, which functions downstream of LET-60 to regulate differentiation of a number of cell types

F57H12.1

arf-3

ADP-ribosylation factor homolog, a GTPase that regulates intracellular trafficking and the actin cytoskeleton

R13H7.1^a

srx-20

Serpentine receptor, class X

K06A4.3

gsnl-1

Gelsolin-related protein predicted to function as an actin regulatory protein, capping barbed ends of actin filaments

Y49A3A.2^a

Uncharacterized

F33E11.1^a

nhr-15

A nuclear hormone receptor

E02C12.3^a

srx-47

Serpentine receptor, class X

F53A9.10^a

tnt-2

Troponin, a tropomyosin binding protein

C54D1.5^a

lam-2

Subunit of laminin required for basement membrane integrity and gonad morphology