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Table 1 Comparison of SNPs identified by BVSR and LPG between T1D and RA

From: LPG: A four-group probabilistic approach to leveraging pleiotropy in genome-wide association studies

 

snp

chr

position

sep T1D

sep RA

joi T1D

joi RA

1

rs6679677

1

114303808

< 1e-17a (0.3494)

4.66e-13a (0.3161)

< 1e-17a (0.3504)

< 1e-17a (0.2944)

2

rs13200022

6

31098957

2.22e-16a (-0.3371)

1 (-0.0309)

< 1e-17a (-0.3380)

2.29e-14a (-0.0670)

3

rs550513

6

31920687

2.14e-05a (-0.2315)

9.96e-01 (-0.1355)

8.76e-09a (-0.2325)

8.76e-09a (-0.1458)

4

rs3130287

6

32050544

< 1e-17a (-0.4659)

1 (-0.0650)

< 1e-17a (-0.4668)

3.29e-14a (-0.0603)

5

rs17421624

6

32066177

1.1e-08a (-0.2672)

< 1e-17a (0.3801)

< 1e-17a (-0.2686)

< 1e-17a (0.2570)

6

rs9272346

6

32604372

< 1e-17a (-0.7077)

1 (-0.0888)

< 1e-17a (-0.7089)

3.73e-14a (-0.0579)

7

rs2070121

6

32781554

4.44e-16a (-0.3331)

1 (-0.0597)

< 1e-17a (-0.3335)

2.22e-16a (-0.1199)

8

rs10484565

6

32795032

< 1e-17a (0.3786)

1 (0.0838)

< 1e-17a (0.3797)

< 1e-17a (0.1541)

9

rs241427

6

32804414

1e-04a (-0.2236)

9.98e-01 (-0.1283)

6.1e-06a (-0.2237)

6.1e-06a (-0.1005)

10

rs10759987

9

121364134

1.66e-03a (-0.2082)

1 (0.0272)

6.76e-03a (-0.2083)

6.76e-03a (0.0208)

11

rs17696736

12

112486818

9.86e-06a (0.2354)

1 (0.0570)

1.18e-05a (0.2358)

1.18e-05a (0.0560)

  1. Results from the analysis of the dataset consisting of 58C controls with RA and UKBS controls with T1D. Two types of analysis were conducted: separate (“sep”) analysis using BVSR and joint (“joi”) analysis using LPG. The last 4 columns of the table give the local false discovery rates (lfdr) and estimated coefficients (in parentheses) for SNPs identified by BVSR and LPG between T1D and RA
  2. adenotes lfdr < 0.2