Fig. 4

Mutational spectrum of the rat exome-seq data. a All exonic variants captured across all samples in the 71 Mb design (50 Mb + UTRs) plus the dbSNP variants were plotted using the Kullback-Leibler divergence. a A high frequency of C > T and T > C mutations presented with minimal observed differences in the mutational spectrum across all samples and dbSNP. b Hierarchical clustering grouped dbSNP with the normal, FF-FFPE tissue and showed divergence of these groups from the tumor cell lines