Table 2 Association results of five novel SNPs in Phase 1, Phase 2, and the Phase 1 + 2 meta-analysis
SNP | CHR:Position(bp)a | Geneb | Coded allele | Non-coded allele | Facial traits | Association results |  | Meta-analysis (Phase 1 + 2) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|  | AF | beta ± se | P-value |  | beta ± se | P-value | Q | I2 | ||||||
rs7567283 | 2:19,595,772 | OSR1-WDR35 | G | A | Right facial angle of en-ex-go | Phase 1 | 0.24 | −0.572 ± 0.109 | 1.72 × 10−7 |  | − 0.536 ± 0.096 | 2.75 × 10 −8 | 0.48 | 0.00 |
Phase 2 | 0.24 | − 0.410 ± 0.205 | 0.046 |  |  |  |  |  | ||||||
rs970797 | 2:176,820,065 | HOXD1-MTX2 | A | C | Tangent line angle of el3 | Phase 1 | 0.33 | 0.017 ± 0.003 | 4.90 × 10 −8 |  | 0.015 ± 0.003 | 7.40 × 10 −9 | 0.29 | 12.52 |
Phase 2 | 0.34 | 0.011 ± 0.005 | 0.030 |  |  |  |  |  | ||||||
Tangent line angle of er3 | Phase 1 | 0.33 | 0.015 ± 0.003 | 4.51 × 10−7 |  | 0.015 ± 0.003 | 3.97 × 10 − 9 | 0.93 | 0.00 | |||||
Phase 2 | 0.34 | 0.014 ± 0.005 | 0.003 |  |  |  |  |  | ||||||
rs3736712 | 6:169,699,889 | WDR27 | C | T | Eye tail length | Phase 1 | 0.37 | 0.322 ± 0.055 | 5.89 × 10 −9 |  | 0.293 ± 0.048 | 8.44 × 10 −10 | 0.30 | 6.92 |
Phase 2 | 0.38 | 0.208 ± 0.095 | 0.029 |  |  |  |  |  | ||||||
rs2193054 | 17:67,537,404 | SOX9 | C | G | Profile nasal angle | Phase 1 | 0.47 | −0.007 ± 0.001 | 1.43 × 10 −11 |  | −0.007 ± 0.001 | 6.17 × 10 − 17 | 0.22 | 33.67 |
Phase 2 | 0.46 | −0.009 ± 0.002 | 4.60 × 10− 7 |  |  |  |  |  | ||||||
Nasal tip protrusion | Phase 1 | 0.47 | 0.019 ± 0.003 | 1.93 × 10 −8 |  | 0.017 ± 0.003 | 5.34 × 10 −9 | 0.23 | 31.80 | |||||
Phase 2 | 0.46 | 0.011 ± 0.005 | 0.050 |  |  |  |  |  | ||||||
rs2206437 | 20:37,426,155 | DHX35 | A | T | Subnasal width | Phase 1 | 0.26 | −0.272 ± 0.054 | 4.75 × 10− 7 |  | − 0.283 ± 0.047 | 1.61 × 10 −9 | 0.69 | 0.00 |
Phase 2 | 0.28 | − 0.316 ± 0.095 | 8.67 × 10−4 |  |  |  |  |  | ||||||