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Table 5 Gene ontology analysis of the predicted interactions {Rv0849, ABCB1} and {Rv1988, PNP}. Rv0849 is classified into the drug resistance type of antibiotic efflux pumps [46]. Rv1988 is classified into the drug resistance type of target-modifying enzymes [46]

From: Transferring knowledge of bacterial protein interaction networks to predict pathogen targeted human genes and immune signaling pathways: a case study on M. tuberculosis

{Rv0849, ABCB1} GO term ID GO aspect GO term name
Common GO terms GO:0055085 P transmembrane transport
GO:0006810 P transport
GO:0005886 C plasma membrane
GO:0016021 C integral to membrane
ABCB1 only GO:0005215 F transporter activity
GO:0006855 P drug transmembrane transport
GO:0042908 P xenobiotic transport
GO:0009986 C cell surface
GO:0070062 C extracellular vesicular exosome
GO:0002485 P antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent
{Rv1988, PNP} GO term ID GO aspect GO term name
Common GO terms GO:0005737 C cytoplasm
GO:0016740 F transferase activity
Rv1988 only GO:0000154 P rRNA modification
GO:0008649 F rRNA methyltransferase activity
GO:0031167 P rRNA methylation
GO:0046677 P response to antibiotic
PNP only GO:0006139 P nucleobase-containing compound metabolic process
GO:0006148 P inosine catabolic process
GO:0006195 P purine nucleotide catabolic process
O:0006738 P nicotinamide riboside catabolic process
GO:0006955 P immune response
GO:0042493 P response to drug
GO:0070970 P interleukin-2 secretion
GO:0034356 P NAD biosynthesis via nicotinamide riboside salvage pathway
  1. C denotes cellular component, F denotes molecular function, and P denotes biological process