Table 5 Gene ontology analysis of the predicted interactions {Rv0849, ABCB1} and {Rv1988, PNP}. Rv0849 is classified into the drug resistance type of antibiotic efflux pumps [46]. Rv1988 is classified into the drug resistance type of target-modifying enzymes [46]

Common GO terms

GO:0055085

P

transmembrane transport

GO:0006810

P

transport

GO:0005886

C

plasma membrane

GO:0016021

C

integral to membrane

ABCB1 only

GO:0005215

F

transporter activity

GO:0006855

P

drug transmembrane transport

GO:0042908

P

xenobiotic transport

GO:0009986

C

cell surface

GO:0070062

C

extracellular vesicular exosome

GO:0002485

P

antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent

{Rv1988, PNP}

GO term ID

GO aspect

GO term name

Common GO terms

GO:0005737

C

cytoplasm

GO:0016740

F

transferase activity

Rv1988 only

GO:0000154

P

rRNA modification

GO:0008649

F

rRNA methyltransferase activity

GO:0031167

P

rRNA methylation

GO:0046677

P

response to antibiotic

PNP only

GO:0006139

P

nucleobase-containing compound metabolic process

GO:0006148

P

inosine catabolic process

GO:0006195

P

purine nucleotide catabolic process

O:0006738

P

nicotinamide riboside catabolic process

GO:0006955

P

immune response

GO:0042493

P

response to drug

GO:0070970

P

interleukin-2 secretion

GO:0034356

P

NAD biosynthesis via nicotinamide riboside salvage pathway