Table 6 GO and pathway enrichment analysis of the M. tuberculosis H37Rv genes that are predicted to target human TNF-alpha and IL-1~IL11 signaling pathways

TNF-Alpha

GO term ID

GO aspect

GO term name

%

Shared

MTB genes that target human gene PSMC2

GO:0005524

F

ATP binding

26.92

Yes

GO:0016020

C

membrane

20.51

Yes

GO:0055114

P

oxidation-reduction process

16.67

No

GO:0016310

P

phosphorylation

5.98

No

GO:0006412

P

translation

5.13

No

GO:0055085

P

transmembrane transport

2.14

Yes

GO:0046933

F

hydrogen ion transporting ATP synthase activity, rotational mechanism

1.71

No

Human gene PSMC2

GO:0002479

P

antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent

–

–

GO:0043687

P

post-translational protein modification

–

–

GO:0045899

P

positive regulation of RNA polymerase II transcriptional preinitiation complex assembly

–

–

Targeted human genes

IL-1 ~ IL-11

GO term ID

GO aspect

GO term name

%

Shared

M.TB genes that target the human gene VCP

GO:0003824

F

catalytic activity

32.17

No

GO:0016021

C

integral to membrane

16.78

No

GO:0005524

F

ATP binding

27.27

Yes

GO:0055114

P

oxidation-reduction process

9.79

No

GO:0006810

P

transport

3.50

Yes

GO:0006281

P

DNA repair

2.10

No

Human gene VCP

GO:0005515

F

protein binding

–

–

GO:0006914

P

autophagy

–

–

GO:0016236

P

macroautophagy

–

–

GO:0010918

P

positive regulation of mitochondrial membrane potential

–

–

GO:0006974

P

cellular response to DNA damage stimulus

–

–