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Table 6 GO and pathway enrichment analysis of the M. tuberculosis H37Rv genes that are predicted to target human TNF-alpha and IL-1~IL11 signaling pathways

From: Transferring knowledge of bacterial protein interaction networks to predict pathogen targeted human genes and immune signaling pathways: a case study on M. tuberculosis

TNF-Alpha GO term ID GO aspect GO term name % Shared
MTB genes that target human gene PSMC2 GO:0005524 F ATP binding 26.92 Yes
GO:0016020 C membrane 20.51 Yes
GO:0055114 P oxidation-reduction process 16.67 No
GO:0016310 P phosphorylation 5.98 No
GO:0006412 P translation 5.13 No
GO:0055085 P transmembrane transport 2.14 Yes
GO:0046933 F hydrogen ion transporting ATP synthase activity, rotational mechanism 1.71 No
Human gene PSMC2 GO:0002479 P antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0043687 P post-translational protein modification
GO:0045899 P positive regulation of RNA polymerase II transcriptional preinitiation complex assembly
Targeted human genes CASP10,BID,RUVBL2,DDX21,RPL4,BRINP1,PSMC2,PSMD1,FANCD2,MTIF2,PSMD2,PSMB5,RPS11,PSMC3,GLUL,PDCD2,KTN1
IL-1 ~ IL-11 GO term ID GO aspect GO term name % Shared
M.TB genes that target the human gene VCP GO:0003824 F catalytic activity 32.17 No
GO:0016021 C integral to membrane 16.78 No
GO:0005524 F ATP binding 27.27 Yes
GO:0055114 P oxidation-reduction process 9.79 No
GO:0006810 P transport 3.50 Yes
GO:0006281 P DNA repair 2.10 No
Human gene VCP GO:0005515 F protein binding
GO:0006914 P autophagy
GO:0016236 P macroautophagy
GO:0010918 P positive regulation of mitochondrial membrane potential
GO:0006974 P cellular response to DNA damage stimulus
  1. Targeted human genes BCL2L11,UNC119,IRS1,IL2,DOK2,PTPN6,BAD,IL11,VCP,IRS2
  2. C denotes cellular component, F denotes molecular function, and P denotes biological process