Fig. 6

H4K20me3 and H3K4me3 occupy L1 and ERVK family repetitive elements in ES cells. a Annotation of H4K20me3/H3K4me3, H4K20me3, and H3K4me3 enriched regions (left) and H3K9me3/H3K4me3, H3K9me3, and H3K4me3 regions (right) in ES cells using HOMER software. b LINE class and L1 family of repetitive DNA sequences are enriched in H4K20me3/H3K4me3 co-occupied regions, H4K20me3 regions, and H3K9me3 regions. Empirical cumulative distribution plots for the percent coverage of LINE repeats (left) or the L1 repeat family member (right) across H4K20me3/H3K4me3 co-marked regions (orange), H4K20me3 regions (blue), H3K9me3 regions (blue), or H3K4me3 regions (blue) relative to their respective random genomic regions (black). Y-axis shows the percentage of genes with a percent repeat length less than the value specified by the x-axis. A line shifted to the right means a systematic increase in the percent coverage of a repeat element in ChIP-Seq peaks relative to random genomic sequences. P-value for all < 2.2e-16 (Kolmogorov-Smirnov test). c Annotation of H4K20me3/H3K36me3, H4K20me3, and H3K36me3 enriched regions (left) and H3K9me3/H3K36me3, H3K9me3, and H3K36me3 regions (right) in ES cells using HOMER software. d LTR repetitive DNA sequence classes are enriched in H4K20me3/H3K36me3 co-occupied regions. Empirical cumulative distribution for the percent coverage of LTR repeats (left) or the ERVK repeat family member (right) across H4K20me3/H3K36me3 co-marked regions (orange), H4K20me3 regions (blue), H3K9me3 regions (blue), or H3K4me3 regions (blue) relative to their respective random genomic regions (black). Y-axis shows the percentage of genes with a percent repeat length less than the value specified by the x-axis. A line shifted to the right means a systematic increase in the percent coverage of a repeat element in ChIP-Seq peaks relative to random genomic sequences. P-value for all < 2.2e-16 (Kolmogorov-Smirnov test)