Fig. 1

Initial model growth predictions validation. Comparison of the specific growth rate predicted in silico with different models to the measured growth rates in chemostat data [55] with a glucose-limited minimal defined media. The published data on the rate of glucose uptake, oxygen consumption, CO₂ production and γ-actinorhodin production for seven different conditions were used as metabolic constraints in the different models. Growth prediction by iAA1259 shows a slight improvement compared to its immediate predecessor, iMK1208 [22]