Fig. 2

Comparison of dynamic cell growth predictions. The quantitative in silico growth predictions are compared to measured biomass and predictions with previously published models across time points. The models were constrained using phosphate, glucose, and glutamate consumption, as well as production of the antibiotics actinorhodin and undecylprodigiosin measured in a fermenter experiment [57]. The updated model’s predictions are closer to experimental observations than those of previous models, showing a significant improvement in growth prediction with the iAA1259 model