Fig. 3

The mutational processes are associated with the somatic status of the SMGs. The activity of the “NpCpG” signature is associated with the somatic statuses of PTHC1 (a). The activity of the “AID/APOBEC-2” signature is associated with the somatic statuses of FBXW7 and PIK3CA (b). The somatic statuses of TP53 is associated with the activity of the “NpCpG” signature (c) and the “AID/APOBEC-2” signature (d). The FDR is based on the adjusted Wilcoxon rank-sum test P values. The effects for the somatic status and the genetic burden of TP53 on the activity of the “NpCpG” signature (e) and the “AID/APOBEC-2” signature (f) are shown with other clinical features. The P values are based on multivariate regression analysis: *P < 0.05, **P < 0.01, ***P < 0.001