Fig. 7From: Whole-transcriptome changes in gene expression accompany aging of sensory neurons in Aplysia californicaActivation of the iNOS pathway with age. Production of nitric oxide via iNOS was predicted to increase in aged neurons. Two transcriptional activators of iNOS, MAPK and NF-Κb, increased expression (padj≤0.05). A third, STAT1, was predicted by IPA to have increased expression. High concentrations of nitric oxide have been implicated in aging and may result in increased DNA damage, apoptosis, and neuronal deathBack to article page