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Table 1 Subset of wolf-like (a) and dog-like (b) outlier genes detected in Czechoslovakian Wolfdogs analysed in this study which have been previously described in the canid literature

From: Wolf outside, dog inside? The genomic make-up of the Czechoslovakian Wolfdog

Gene name Methods Chr Start (bp) End (bp) Reference Association
a
CRHBP BayeScan 3 29,726,312 29,738,001 [60] Social behavior and maternal aggression
NPHP4 PCAdmix, GO 5 59,805,955 59,936,808 [64] Bone and retinal disorder
ENO1 PCAdmix 5 62,301,164 62,312,161 [57] Related to mRNA transcript variants, genes responsible for bone and cartilage tissues
ASTN2 BGC 11 70,248,612 70,977,896 [57] Related to mRNA transcript variants, genes responsible for bone and cartilage tissues
PCDH15 BGC, GO 26 33,962,360 34,571,935 [63] Vision regulation and hearing abilities
BMP3 BGC 32 5,207,833 5,231,966 [58] Morphological features: paws and bones
b
ARID1B PCAdmix 1 46,370,636 46,799,104 [68] Cellular responses, DNA repair
URI1 BGC, GO 1 121,528,137 121,612,185 [57] DNA-binding
RPE65 FST SNP 6 76,887,399 76,911,146 [64, 67] Dog diseases (Leber congenital amaurosis)
EPAS1 PCAdmix, GO 10 48,551,410 48,634,643 [77] Environmental adaptation
ASCC3 PCAdmix, GO 12 58,592,025 58,932,720 [68] Cellular responses, DNA repair
GRIK2 PCAdmix, GO 12 59,590,231 59,992,091 [68] Lipid metabolism
SMARCD3 PCAdmix, GO 16 15,279,418 15,289,275 [77] Muscle cell differentiation, heart morphogenesis
ZMAT4 FST SNP, PCAdmix 16 24,561,867 24,889,045 [57] DNA-binding
ADAM9 PCAdmix , GO 16 26,410,907 26,551,122 [64] Dog diseases (cone-rod dystrophy)
STRN FST SNP 17 29,273,978 29,365,239 [78] Dog diseases (arrhythmogenic right ventricular cardiomyopathy)
MGST2 PCAdmix 19 3,067,163 3,070,563 [68] Cellular responses, DNA repair
NOCT PCAdmix, GO 19 3,589,720 3,607,191 [65] Circadian rhythms, body weight and digestion
SLC7A11 PCAdmix 19 4,289,915 4,371,635 [68] Lipid metabolism
CNTN5 PCAdmix 21 1,128,048 1,614,989 [20] Nervous system differentation
OXT PCAdmix 24 18,193,429 18,194,002 [69] Learning and memory processes
CBDs PCAdmix 24 20,614,030 20,971,219 [68] Immune system
DEFB119 PCAdmix 24 20,905,210 20,918,355 [68] Immune system
HM13 PCAdmix, GO 24 21,026,827 21,067,920 [68] Cellular responses, DNA repair
RALY ROH 24 23,211,141 23,262,511 [46] Coat color
ASIP ROH 24 23,354,642 23,393,918 [20, 46] Coat color, social behavior
NCOA6 ROH 24 23,802,887 23,866,792 [68] Co-activation of several hormone-dependent receptors
ACSS2 ROH 24 23,928,670 23,972,633 [68] Lipid metabolism
TMEM132D FST SNP, PCAdmix 26 2,074,728 2,662,470 [68] Oligodendrocyte differentiation, metabolism
CUX2 PCAdmix, GO 26 8,730,082 8,996,271 [68] DNA-binding
SEZ6L PCAdmix, GO 26 19,889,395 20,079,319 [70] Social behavior
ARVCF BGC, PCAdmix, GO 26 29,314,144 29,534,294 [70] Polydactyly and morphological features
COMT PCAdmix, GO 26 29,360,372 29,366,006 [70] Social behavior (aggression and attention regulation)
PCDH15 BayeScan, PCAdmix, FST SNP, GO 26 33,962,360 34,571,935 [63] Polydactyly and morphological features, vision and hearing abilities, communication and behavior
BMPR1B PCAdmix, GO 32 17,819,265 17,978,113 [66] Polydactyly and morphological features
UNC5C FST SNP, PCAdmix, GO 32 17,987,785 18,332,959 [66] Tumor suppression
BANK1 PCAdmix, GO 32 23,281,315 23,603,279 [67] Regulation processes of calcium ions
TGIF1 PCAdmix 32 32,950,116 32,950,934 [66] Nervous system differentation
IGF2BP2 PCAdmix 34 18,368,131 18,522,156 [75, 76] Lipid metabolism
MARCH7 BGC 36 5,499,129 5,531,823 [43] Cellular responses, DNA repair
NHEJ1 PCAdmix, GO 37 25,633,562 25,719,307 [80] Dog diseases (Collie eye anomaly)
SLC4A3 PCAdmix 37 26,136,624 26,149,312 [64, 79] Dog diseases (progressive retinal atrophy)