Fig. 3

Two-way hierarchical clustering of representative genes selected from all three brain regions. Genes modulated more than 1.5 or less than 0.5 are clustered (Euclidean distance, average linkage) into the heatmap from all three brain regions (hippocampus [HC], frontal cortex [FC] and the dorsal raphe [DR]) of Dark Agouti rats 3 weeks after a single-dose of (15 mg/kg, intraperitoneal) MDMA. The brain regions are unequivocally separated by this analysis, suggesting markedly different effects of MDMA in the different regions. See text for further details