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Table 3 Biologically Relevant Processes with Enriched Gene Sets in the Hippocampal Region

From: Gene expression analysis indicates reduced memory and cognitive functions in the hippocampus and increase in synaptic reorganization in the frontal cortex 3 weeks after MDMA administration in Dark Agouti rats

Biological Process Number of Enriched Gene Sets Related to the Term Direction
Protein Phosphorylation 4
Dendrite and synapse development 4
Synaptic plasticity 4
Transmembrane transport 2
Others 2
Memory, cognition 2
  1. This table summarizes the biological processes significantly altered in the hippocampus of Dark Agouti rats after a single-dose 3,4-methylenedioxymethamphetamine (MDMA) treatment (15 mg/kg, intraperitoneal) 3 weeks earlier. The processes were created based on the network analysis of gene set enrichment analysis and individual considerations. All significantly enriched GO terms are included in one of the processes. Downward arrows represent downregulations. See text for further details