Fig. 3

Intra-patient evolution and mutation rates. a The numbers of SNPs of the bacterial isolates at different stages of treatment for each patient. A, B, C, and D represent the four selected patients. The number on the short line indicates the numbers SNPs between two isolates at different time points of treatment of the same patient. b Pie chart depicting distribution of SNPs. Outer: patients compared with H37Rv; Inner: intra-patient. c Violin plot of calculated pairwise mutation rates per year between any pair of strains