Fig. 4
From: Nascent RNA sequencing analysis provides insights into enhancer-mediated gene regulation
Impact of Hdac3 deletion on nascent transcription of known genes. a Heatmap of log2-transformed fold changes of RNA polymerases ±5 kb from TSSs with 200 bp bin size for all active genes comparing Hdac3 KO (knockout) and WT (wildtype) mouse livers. Genes were ranked by promoter-proximal density changes. b Heatmap of log2-transformed fold changes in RNA polymerases ±5 kb from TSSs with 200 bp bin size for genes showing significant change in RNA polymerases in promoter-proximal regions (pp up: upregulated in promoter-proximal regions; pp. down: downregulated in promoter-proximal regions; gb up: upregulated in gene body region; gb down: downregulated in gene body region; gb unchanged: unchanged in gene body region). c IGV snapshot of an example that shows a concomitant increase of RNA transcription in promoter-proximal but no change in gene body upon Hdac3 deletion