Table 1 Measured landscape descriptors and biochemical parameters (reported in [30, 31]) with correlations ≥0.5. T-* indicates the hydrolyzed T-state
From: From mutations to mechanisms and dysfunction via computation and mining of protein energy landscapes
State | d(State, Saddle) | dE(State, Saddle) |
|---|---|---|
On | P7(-0.84), P3(0.53) | – |
Off | P7(0.83) | P7(0.58), P0(0.54), P8(0.50) |
T- | P7(-0.79) | P0(0.62) |
R- | P7(-0.85), P3(0.51) | P7(0.61), P0(0.51) |
T*- | P7(-0.82) | P7(0.62), P0(0.54), P8(0.53) |