Genome-wide transcriptome analysis using RNA-Seq reveals a large number of differentially expressed genes in a transient MCAO rat model

Table 4 Analysis of the functional categories of the proteins encoded by DEGs

Functional Categories	IR4.5 vs. SH4.5			IR24 vs. SH24			IR24 vs. IR4.5
Functional Categories	Up	Down	Padj	Up	Down	Padj	Up	Down	Padj
Innate immunity	10	3	5.04E-04	35	3	2.17E-09	30	10	9.38E-07
Inflammatory response	12	0	5.89E-05	16	2	6.39E-03	10	10	3.73E-02
Stress response	7	0	2.80E-03	12	0	1.70E-02
Differentiation	14	3	3.38E-02	29	24	1.62E-03	31	42	1.58E-04
Cell adhesion	12	4	2.20E-02	29	23	7.52E-05	28	30	6.19E-03
Transcription regulation	35	5	3.54E-04	67	48	1.77E-04	51	108	9.26E-06
DNA replication				14	0	4.54E-03	16	4	1.31E-04
Adaptive immunity				13	4	5.51E-05	11	6	2.20E-03
Apoptosis				38	10	3.38E-04	41	14	9.35E-03
Synapse				2	58	4.10E-07	3	84	1.19E-11
Ion channel				10	43	8.05E-05	17	71	5.76E-12
Proteasome							21	1	1.30E-06
Ribosomal protein							73	4	8.77E-11
Translation regulation							10	3	4.80E-02
Neurogenesis				9	23	1.30E-04	7	29	2.17E-03

Associative analysis of DEGs for comparison groups under ischemia–reperfusion conditions was carried out according to the DAVID database. The number of up-regulated (Up) and down-regulated (Down) DEGs in the condition of the tMCAO model, as well as the P-values adjusted using the Benjamini–Hochberg procedure (Padj), are shown

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