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Table 4 Analysis of the functional categories of the proteins encoded by DEGs

From: Genome-wide transcriptome analysis using RNA-Seq reveals a large number of differentially expressed genes in a transient MCAO rat model

Functional Categories IR4.5 vs. SH4.5 IR24 vs. SH24 IR24 vs. IR4.5
Up Down Padj Up Down Padj Up Down Padj
Innate immunity 10 3 5.04E-04 35 3 2.17E-09 30 10 9.38E-07
Inflammatory response 12 0 5.89E-05 16 2 6.39E-03 10 10 3.73E-02
Stress response 7 0 2.80E-03 12 0 1.70E-02    
Differentiation 14 3 3.38E-02 29 24 1.62E-03 31 42 1.58E-04
Cell adhesion 12 4 2.20E-02 29 23 7.52E-05 28 30 6.19E-03
Transcription regulation 35 5 3.54E-04 67 48 1.77E-04 51 108 9.26E-06
DNA replication     14 0 4.54E-03 16 4 1.31E-04
Adaptive immunity     13 4 5.51E-05 11 6 2.20E-03
Apoptosis     38 10 3.38E-04 41 14 9.35E-03
Synapse     2 58 4.10E-07 3 84 1.19E-11
Ion channel     10 43 8.05E-05 17 71 5.76E-12
Proteasome        21 1 1.30E-06
Ribosomal protein        73 4 8.77E-11
Translation regulation        10 3 4.80E-02
Neurogenesis     9 23 1.30E-04 7 29 2.17E-03
  1. Associative analysis of DEGs for comparison groups under ischemia–reperfusion conditions was carried out according to the DAVID database. The number of up-regulated (Up) and down-regulated (Down) DEGs in the condition of the tMCAO model, as well as the P-values adjusted using the Benjamini–Hochberg procedure (Padj), are shown