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Table 2 Top five genes based on gene-based association statistics for resistance to clinical mastitis

From: Prioritizing candidate genes post-GWAS using multiple sources of data for mastitis resistance in dairy cattle

Lead SNP Top 5 Genes* Gene P value
3:92927352 PLPP3, TXNDC12, RAB3B, NRDC, ENSBTAG00000046915 1.46e-08
4:10928348 ASB4, ANKIB, COL28A1, DYNC1I1, PON1 1.83e-06
4:58490979 TBX20, IMMP2L, ST7, LAMB4, ELMO1 9.77e-09
5:30211323 SLC2A13, SLC38A1, RPAP3, TMEM117, LIMA1 6.80e-10
5:106360448 CCDC77, LOC100336690,ABCC9,KDM5A, FGF6 1.56e-08
6:23469606 TBCK, TSPAN5, PPA2, PPP3CA, NFKB1 1.33e-09
6:87299659 NPFFR2, SULT1E1, SLC4A4, DCK, LOC100140490 2.50e-26
6: 93131207 PARM1, SHROOM3, MTHFD2L, SEPT11, EPGN 2.16e-14
7:31253987 C3, PCDHB11, PCDHB6, FBN3, LOC786512 1.27e-08
8:25684799 ADAMTSL1, MLLT3, PLPPR1, MTAP, FOCAD 3.15e-08
9:80007099 ESR1, RAET1G, PPP1R14C, SYNE1, SHPRH 4.16e-07
10:51191670 RORA, MYO1E, RNF111, DUOX1,SLC28A2 2.93e-08
11:88742878 PDIA6, ATP6V1C2, CAPG, TBC1D8, MGAT4A 4.43e-08
13:62017506 BMP7, TFAP2C, NSFL1C, NDRG3, REM1 2.01e-14
14:61344981 DPYS, KCNQ3, TPD52, RSPO2, PARP10 1.44e-07
16:47836093 SMYD3, ACOT7, MEGF6, ENSBTAG00000019339, CHD5 8.28e-13
18:43909571 HPN, GPI, WTIP, PDCD2L, TGFB1 7.08e-09
19:43038655 SP2, TBCD, OSBPL7, SRCIN1, CBX1 2.22e-13
20:38471456 PLCXD3, WDR70, RICTOR, MROH2B, NUP155 2.99e-14
23:11477905 ZFAND3, CPNE5, DNAH8, KCTD20, PPARD 1.05e-11
25:35354412 TMEM130, CORO7, VASN, CDIP1, DNAJA3 2.09e-08
26:20463679 PDE6C, BTRC, SEMA4G, CNNM2, SLK 7.43e-09
  1. *Top five genes selected based on the ranking of P value, if the –log10 (P) > 5.60, the genes are listed in the table
  2. # The P value listed in the table is for the gene with highest P value among the top five genes showing association. The model to calculate the gene P value in MAGMA [17] was snp-wise = mean