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Fig. 1 | BMC Genomics

Fig. 1

From: Bivariate genome-wide association analysis strengthens the role of bitter receptor clusters on chromosomes 7 and 12 in human bitter taste

Fig. 1

Illustration of three scenarios in a bivariate analysis. Each dot represents an individual, colored according to their genotype (0, 1 or 2 copies of the minor allele). In (a) trait 1 and 2 are correlated but the variant is only associated with trait 1. When considering traits 1 and 2 jointly in testing for association, there is greater separation of the genotype groups for trait 1 in the two-dimensional space compared with the y-axis alone. For example, the blue and green dots would largely overlap in the one-dimensional space along the y-axis. In (b) the minor allele has opposite effects on traits 1 and 2 - increasing trait 1 and decreasing trait 2. The three genotype groups are better separated in the two-dimensional space than for either trait individually. In (c) the minor allele has a similar effect on traits 1 and 2 - increasing both traits. Separation of the three genotype groups in two-dimensional space is no greater than along the y-axis alone. The figures and text are adapted from Fig. 1 in Stephens (2013) [29]

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