Table 3 IPA summary of the liver transcriptome in the E18 vs. E20 contrast
Top Canonical Pathways | p-value | Overlap | Ratio |
LPS/IL-1 Mediated Inhibition of RXR Function | 1.11E-04 | 13.4% | 18/134 |
Mitotic Roles of Polo-Like Kinase | 1.22E-04 | 20.4% | 10/49 |
Protein Ubiquitination Pathway | 4.53E-04 | 10.9% | 22/202 |
Unfolded protein response | 9.41E-04 | 19.0% | 8/42 |
Tyrosine Degradation I | 1.14E-03 | 60.0% | 3/5 |
Top Upstream Regulators | p-value of overlap | # Target genes | |
PPARA | 6.04E-14 | 47 | |
TCF3 | 1.11E-11 | 38 | |
ATF6 | 1.56E-08 | 13 | |
FOXO3 | 5.68E-08 | 32 | |
RARA | 6.84E-08 | 30 | |
Top Molecular and Cellular Functions | p-value | # Genes | |
Amino Acid Metabolism | 2.43E-03 - 1.01E-12 | 42 | |
Small Molecule Biochemistry | 3.58E-03 - 1.01E-12 | 161 | |
Cell Cycle | 3.01E-03 - 5.43E-10 | 82 | |
Cell Morphology | 2.92E-03 - 1.29E-09 | 39 | |
Cellular Assembly and Organization | 2.92E-03 - 1.29E-09 | 43 | |
Physiological System Development and Function | p-value | # Genes | |
Hematological System Development and Function | 2.85E-03 - 2.16E-05 | 23 | |
Lymphoid Tissue Structure and Development | 2.43E-03 - 2.16E-05 | 17 | |
Organ Morphology | 2.43E-03 - 2.16E-05 | 55 | |
Tissue Morphology | 2.43E-03 - 2.16E-05 | 25 | |
Organismal Development | 3.07E-03 - 2.64E-05 | 68 | |
Top Toxicity Functions | p-value | Overlap | Ratio |
Fatty Acid Metabolism | 7.84E-05 | 18.2% | 12/66 |
LPS/IL-1 Mediated Inhibition of RXR Function | 2.72E-04 | 12.4% | 18/145 |
FXR/RXR Activation | 1.62E-03 | 13.9% | 11/79 |
Cell Cycle: G2/M DNA Damage Checkpoint Regulation | 3.55E-03 | 17.1% | 7/41 |
PXR/RXR Activation | 3.55E-03 | 17.1% | 7/41 |
Top Up-regulated Genes | log2 Ratio | Top Down-regulated Genes | log2 Ratio |
DIO3 | 3.81 | DIO2 | −5.61 |
ANGPTL3 | 3.14 | SERPINA3 | −4.54 |
SLC2A5 | 2.99 | FABP1 | −3.93 |
RET | 2.83 | HIGD1A | −3.81 |
GAS2 | 2.70 | HMGCS1 | −3.78 |
HDAC9 | 2.69 | KLF9 | −3.52 |
NAV2 | 2.47 | C6 | −3.44 |
CHODL | 2.46 | HPX | −3.38 |
SLC13A3 | 2.45 | FKBP5 | −3.28 |
SOX9 | 2.36 | SLCO1A2 | −3.26 |