Table 5 IPA summary of the liver transcriptome in the E18 vs. D3 contrast
Top Canonical Pathways | p-value | Overlap | Ratio |
Superpathway of Cholesterol Biosynthesis | 2.07E-08 | 73.9% | 17/23 |
Cholesterol Biosynthesis I-III | 3.03E-06 | 90.0% | 9/10 |
Cell Cycle Control of Chromosomal Replication | 4.22E-05 | 45.7% | 21/46 |
Intrinsic Prothrombin Activation Pathway | 6.93E-05 | 60% | 12/20 |
Triacylglycerol Biosynthesis | 8.97E-05 | 50% | 16/32 |
Top Upstream Regulators | p-value of overlap | # Target genes | |
TP53 | 1.00E-21 | 318 | |
PPARA | 5.67E-18 | 115 | |
E2F1 | 9.13E-17 | 125 | |
E2F4 | 5.54E-15 | 75 | |
FOXO3 | 3.82E-13 | 87 | |
Top Molecular and Cellular Functions | p-value | # Genes | |
Cell Cycle | 1.57E-03 - 2.09E-10 | 499 | |
DNA Replication, Recombination, and Repair | 1.38E-03 - 2.09E-10 | 345 | |
Amino Acid Metabolism | 1.57E-03 - 2.48E-10 | 79 | |
Small Molecule Biochemistry | 1.57E-03 - 2.48E-10 | 535 | |
Cellular Assembly and Organization | 1.38E-03 - 6.63E-10 | 326 | |
Physiological System Development and Function | p-value | # Genes | |
Organismal Survival | 9.34E-04 - 8.88E-06 | 682 | |
Embryonic Development | 1.23E-03 - 3.36E-05 | 90 | |
Tissue Morphology | 1.57E-03 - 3.36E-05 | 207 | |
Hematological System Development and Function | 1.38E-03 - 1.83E-04 | 114 | |
Organismal Development | 1.30E-03 - 1.83E-04 | 191 | |
Top Toxicity Functions | p-value | Overlap | Ratio |
Cholesterol Biosynthesis | 8.13E-05 | 66.7% | 10/15 |
NRF2-mediated Oxidative Stress Response | 1.60E-04 | 31.3% | 51/163 |
Liver Necrosis/Cell Death | 2.67E-04 | 29.1% | 64/220 |
LXR/RXR Activation | 3.06E-04 | 37.0% | 27/73 |
TR/RXR Activation | 1.01E-03 | 34.6% | 27/78 |
Top Up-regulated Genes | log2 Ratio | Top Down-regulated Genes | log2 Ratio |
DIO3 | 6.62 | THRSPA | −8.86 |
MOGAT1 | 6.38 | SLCO1A2 | −6.78 |
PDK4 | 5.35 | SQLE | −6.71 |
PPM1K | 5.32 | CDO1 | −6.64 |
RET | 4.59 | ELOVL5 | −6.64 |
ITGBL1 | 4.43 | DIO2 | −6.64 |
ALKAL2 | 4.37 | FASN | −6.48 |
TTLL2 | 4.14 | NSDHL | −6.24 |
SLC13A3 | 4.05 | SCD | −5.71 |
DNAJC12 | 3.89 | CYP7A1 | −5.65 |