Exposure to maternal obesity alters gene expression in the preimplantation ovine conceptus

BMC Genomics

Table 3 Obese versus lean DEGs identified in conceptus samples and associated gene ontology (GO) terms

Gene ID	Fold change, obese vs lean (Log₂)^a	Cellular process	Metabolic process	Cellular component organization	Proliferation, angiogenesis, DNA repair	Obesity and insulin resistance	Placenta^b
MPHOSPH9	8.66					+
INTS12	8.46
CEP57L1	8.41
BRCA1	7.44	+	+	+	+	+	+
ASP	6.65	+	+			+
PAPD4	6.53	+
ALCAM	6.31	+				+	+
RAB4B	5.94
TTK	5.26	+	+
RPS3A	3.66	+	+
TUBA3E	1.62	+		+
PPP2R3A	−4.42	+	+		+
GSTA4	−4.78						+
GP2	−5.55					+	+
DIS3L2	−6.0
FAM213A	−7.12		+
SLC35B3	−7.66	+
PAAF1	−8.04
ERMARD	−8.24
DYNLL2	−8.61	+
TPM1	−8.89	+		+

^arelative fold change (FDR ≤ 0.05, ≥ 2-fold change, ≥ 0.2 RPKM)
^bThe term “Placenta” is not an official GO term. It represents genes identified through a literature search using the search terms “placenta”, “trophectoderm”, and “trophoblast”
“+” indicates the presence of the DEG within the specific GO term

ISSN: 1471-2164