Table 1 Top 10 significantly differentially expressed miRNAs between M-exo vs E-exo/Con-exo/M-cell

miRNA_ID

M-exo

E-exo

up/down

|log2(fold change)|

P-value

miR-26a-5p

342.32

161.34

up

1.09

2.10E-13

miR-92b-3p

65.09

219.15

down

1.75

1.64E-11

miR-193a-5p

16.66

69.67

down

2.06

3.14E-11

miR-424-3p

15.12

68.51

down

2.18

1.43E-10

miR-181b-5p

139.99

62.18

up

1.17

2.40E-09

miR-143-3p

101.23

41.20

up

1.30

3.62E-09

miR-125a-5p

110.20

282.86

down

1.36

2.32E-08

miR-193b-5p

27.52

103.43

down

1.91

2.63E-08

miR-92a-3p

1115.32

2646.67

down

1.25

1.10E-07

miR-3184-3p

641.22

2490.33

down

1.96

1.33E-07

miRNA_ID

M-exo

E-exo

up/down

|log2(fold change)|

P-value

miR-143-3p

476.7317

15.61803

up

4.931893

1.04E-244

miR-181a-2-3p

225.878

62.4662

up

1.854396

9.44E-59

miR-4483

21.115

117.744

down

2.479313

1.16E-21

miR-145-5p

15.63757

0

up

17.25466

1.05E-14

miR-4521

38.8255

123.3244

down

1.667382

6.41E-13

miR-1180-3p

119.0278

254.7887

down

1.098002

8.95E-11

miR-494-3p

47.59617

22.741

up

1.06555

2.24E-09

miR-654-3p

44.7572

20.77677

up

1.107149

2.64E-09

miR-365a-5p

48.06983

23.8603

up

1.01052

8.64E-09

miR-370-3p

27.4212

9.933367

up

1.464937

1.48E-08

miRNA_ID

M-exo

Con-exo

up/down

|log2(fold change)|

P-value

miR-205-5p

8.22

4634.82

down

9.14

2.31E-188

miR-200c-3p

10.84

2762.23

down

7.99

1.45E-63

miR-192-5p

6328.30

700.17

up

3.18

4.67E-56

miR-148a-3p

243.13

6603.26

down

4.76

1.15E-55

miR-10a-5p

289.49

16.94

up

4.09

2.83E-52

miR-203a-3p

22.32

395.25

down

4.15

3.08E-40

miR-381-3p

83.07

3.12

up

4.74

8.54E-34

miR-584-5p

0.00

67.33

down

19.36

1.46E-33

miR-409-3p

44.56

1.92

up

4.54

2.96E-17

miR-127-3p

65.47

5.16

up

3.67

1.45E-18

miRNA_ID

E-exo

Con-exo

up/down

|log2(fold change)|

P-value

miR-205-5p

7.21

4634.82

down

9.33

3.58E-137

miR-10a-5p

561.77

16.94

up

5.05

7.58E-75

miR-148a-3p

321.91

6603.26

down

4.36

5.40E-62

miR-192-5p

8828.24

700.17

up

3.66

1.64E-51

miR-200c-3p

11.53

2762.23

down

7.90

3.65E-49

miR-203a-3p

25.61

395.25

down

3.95

3.58E-38

miR-409-3p

76.15

1.92

up

5.31

1.04E-35

miR-26a-5p

161.34

1570.80

down

3.28

7.03E-35

miR-584-5p

0.43

67.33

down

7.30

4.54E-34

miR-193a-5p

69.67

1.66

up

5.39

7.01E-34

miRNA_ID

M-exo

M-cell

up/down

|log2(fold change)|

P-value

miR-1290

687.15

26.38

up

4.70

2.42E-49

miR-320c

83.16

19.92

up

2.06

2.65E-49

miR-1246

1104.80

185.33

up

2.58

7.24E-49

miR-4497

362.06

2.97

up

6.93

6.46E-47

miR-146b-5p

137.29

40.88

up

1.75

4.34E-43

miR-7704

42.93

2.45

up

4.13

2.40E-35

miR-5787

42.62

0.00

up

18.70

4.57E-21

miR-423-5p

163.74

61.46

up

1.41

1.31E-17

miR-7641

17.91

0.26

up

6.11

2.14E-16

miR-4532

11.44

0.00

up

16.80

7.88E-13