Fig. 2
Acute NE responsive network has immediate-early genes as nodes with high betweenness. a The interaction network reconstructed from DEGs shows nodes with high betweenness. Edges represent experimentally verified protein-protein or protein-DNA interactions. Up-regulated DEGs are in red and down-regulated DEGs in green. Size node is related to betweenness value. b Known immediate-early genes were found to be up-regulated after NE stimulation. Expression values are shown in log2 counts per million (CPM). Expression differences between conditions were analyzed with a Kruskall-Wallis Test, P < 0.0001, Dunn’s Multiple Comparison Test P < 0.05; ET Test, P < 0.05 (*** p < 0.0001, ** p < 0.001)