Fig. 1

Allele specific expression (ASE), parent-of-origin allele specific expression (PO-ASE) and local expression quantitative trait loci (eQTL) diagram. a The gene in the figure has two SNPs in the exons (tSNP₁ and tSNP₂), and their expression can be measured using RNA-Seq and a SNP within 50 kb of the gene which is driving expression of the gene (dSNP). b In the case of PO-ASE, the allele inherited from the dam (in this example) increases the expression of the tSNP allele which is on the maternal chromosome (♀). c When the dSNP has an ASE effect, allele A of the dSNP (in this example) triggers the expression of tSNP allele on the same chromosome. d In local eQTL mapping, the expression of dSNP allele is correlated with total exon expression, where the heterozygote individual for dSNP shows medium expression (A/T, individual 2) and the homozygotes show either high (A/A, individual 1) or low (T/T, individual 3) expression