Fig. 9

Analysis of correlation between α-carbons of TgROP18. In panel a, heatmaps of the average correlation between α-carbons of TgROP18/ATP (upper triangle) and TgROP18/30C (lower triangle). The average was obtained with the four MD trajectories. In panel b, the difference between the maps of panel TgROP18/ATP and TgROP18/30C, i.e., 30C map minus ATP map. We exploited the symmetry of the matrix to show extra information. The upper triangular matrix was left raw. In the identical lower triangular matrix, spots that indicate change of correlation are marked with circles. White triangles and black square marks the region corresponding to intra-lobe and inter-lobe correlation, respectively. In panel c, 3D graph of the change of correlation of TgROP18/30C that was displayed in panel (b). Regions of the protein are displayed as nodes; correlation changes are marked as connections indicating increase (orange) or decrease (blue) of correlation