Fig. 4
From: Important cardiac transcription factor genes are accompanied by bidirectional long non-coding RNAs
The phenotype of Tbx5ua KD chimeric mice. a qRT-PCR of Tbx5ua and Tbx5 in E9.5 chimeric mice that were derived from WT and KD ES cells (n = 4, * p < 0.05, Welch's t-test). Tbx5ua was successfully knocked down. b, c, d The morphology of E9.5 chimeric embryos. KD embryos show right ventricular hypoplasia (c). The ventricular walls of KD embryos appeared abnormally thin (d). e, f The body size and forelimb of KD embryos appeared to be normal in E13.5 chimeric mice, whereas KD embryos showed severe heart defects, including a hypoplastic right ventricle